| Gene Symbol |
LRP4
|
| Entrez Gene |
4038
|
| Alt Symbol |
CLSS, LRP-4, LRP10, MEGF7, SOST2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
low density lipoprotein receptor-related protein 4
|
| Other Description |
low-density lipoprotein receptor-related protein 4|multiple epidermal growth factor-like domains 7
|
| Swissprots |
B2RN39 O75096 Q5KTZ5 Q4AC85
|
| Accessions |
EAW67974 EAW67975 O75096 AB011540 BAA32468 AB084910 BAD83615 AB231861 BAE19679 AK027175 BC037360 AAH37360 BC041048 AAH41048 BC136667 AAI36668 BC136668 AAI36669 BQ446811 DA799511 DB061460 XM_011520102 XP_011518404 XM_011520103 XP_011518405 XM_011520104 XP_011518406 NM_002334 NP_002325
|
| Function |
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. {ECO:0000269|PubMed:20381006, ECO:000026
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain. {ECO:0000269|PubMed:21471202}.
|