LRP4

Gene Symbol	LRP4
Entrez Gene	4038
Alt Symbol	CLSS, LRP-4, LRP10, MEGF7, SOST2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor-related protein 4
Other Description	low-density lipoprotein receptor-related protein 4|multiple epidermal growth factor-like domains 7
Swissprots	B2RN39 O75096 Q5KTZ5 Q4AC85
Accessions	EAW67974 EAW67975 O75096 AB011540 BAA32468 AB084910 BAD83615 AB231861 BAE19679 AK027175 BC037360 AAH37360 BC041048 AAH41048 BC136667 AAI36668 BC136668 AAI36669 BQ446811 DA799511 DB061460 XM_011520102 XP_011518404 XM_011520103 XP_011518405 XM_011520104 XP_011518406 NM_002334 NP_002325
Function	Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. {ECO:0000269|PubMed:20381006, ECO:000026
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain. {ECO:0000269|PubMed:21471202}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LRP4 ELISA Kit (Sandwich ELISA) - LS-F8090 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.126 ng/ml Range 0.313-20 ng/ml

Human LRP4 ELISA Kit (Sandwich ELISA) - LS-F11979 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Human LRP4 ELISA Kit - abx152234 from Abbexa Category ELISA Kit Sensitivity 0.126 ng/ml Range 0.313 ng/ml - 20 ng/ml

Low Density Lipoprotein Receptor Related Protein 4 (LRP4), Human, ELISA Kit - SED747Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.103ng/mL Range 0.312-20ng/mL

Low-density lipoprotein receptor-related protein 4, LRP4, Human, ELISA Kit - E1102h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Low Density Lipoprotein Receptor Related Protein 4 (LRP4), ELISA Kit - MBS2021747 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.126ng/mL. Range 0.313-20ng/mL

low-density lipoprotein-receptor-related protein 4 (LRP-4) antibody (IgG) , ELISA Kit - MBS940575 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

low density lipoprotein receptor-related protein 4, ELISA Kit - MBS943246 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Low Density Lipoprotein Receptor Related Protein 4 (LRP4) - SED747Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.126ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human low-density lipoprotein-receptor-related protein 4(LRP-4)ELISA Kit - CSB-E17518h from Cusabio Category ELISA Kit Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

ELISA Kit for Low Density Lipoprotein Receptor Related Protein 4 (LRP4) - SED747Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.126ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Rat LRP4 ELISA Kit (Custom ELISA) - LS-F16011 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Mouse LRP4 ELISA Kit (Custom ELISA) - LS-F16010 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Low Density Lipoprotein Receptor Related Protein 4 (LRP4), Human, ELISA Kit - DL-LRP4-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human LRP4 ELISA Kit - abx572754 from Abbexa Category ELISA Kit Sensitivity 0.103 ng/ml Range 0.313 ng/ml - 20 ng/ml

LRP4 - EKH2494 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

LRP4 ELISA Kit (Human) : 96 Wells (OKEH00770) - OKEH00770 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.13 ng/mL Range 0.312 - 20 ng/mL

Human LRP4 ELISA Kit - E022973 from Biobool Category ELISA Kit Sensitivity Typically less than 0.126ng/mL.

Human Low-density lipoprotein receptor-related protein 4 ELISA Kit - EK2746 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.13ng/mL Range 0.312-20 ng/mL

anti-LRP4 / LRP10 antibody - ARG64700 from Arigo Biolaboratories Category ELISA Kit

Low Density Lipoprotein Receptor Related Protein 4 (LRP4), ELISA Kit - MBS453918 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.126ng/mL Range 0.312-20ng/mL

Low-density lipoprotein receptor-related protein 4, ELISA Kit - MBS2885711 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Low-density lipoprotein receptor-related protein 4, ELISA Kit - MBS9426583 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.13ng/mL Range 0.312-20 ng/mL

Low-density lipoprotein receptor-related protein 4, ELISA Kit - MBS760221 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Low Density Lipoprotein Receptor Related Protein 4 (LRP4), ELISA Kit - MBS9375985 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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