LRP4

Gene Symbol	LRP4
Entrez Gene	4038
Alt Symbol	CLSS, LRP-4, LRP10, MEGF7, SOST2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor-related protein 4
Other Description	low-density lipoprotein receptor-related protein 4|multiple epidermal growth factor-like domains 7
Swissprots	B2RN39 O75096 Q5KTZ5 Q4AC85
Accessions	EAW67974 EAW67975 O75096 AB011540 BAA32468 AB084910 BAD83615 AB231861 BAE19679 AK027175 BC037360 AAH37360 BC041048 AAH41048 BC136667 AAI36668 BC136668 AAI36669 BQ446811 DA799511 DB061460 XM_011520102 XP_011518404 XM_011520103 XP_011518405 XM_011520104 XP_011518406 NM_002334 NP_002325
Function	Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. {ECO:0000269|PubMed:20381006, ECO:000026
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain. {ECO:0000269|PubMed:21471202}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LRP4 Antibody Blocking Peptide - LS-E26836 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LRP4 blocking peptide - GTX88580-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

Recombinant Human LRP-4, CF - 5948-LR-025 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Human LRP4 protein - orb244355 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Goat anti LRP4 antibody Immunizing peptide - orb17328 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

LRP4 Peptide - AC21-1668-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Low Density Lipoprotein Receptor Related Protein - 20-8827 from ARP American Research Products Category Protein Prices $569.00 Sizes 50 µg Source E.coli Species Human

LRP4 Peptide - 46-951P from ProSci Category Peptide Species Human

LRP4 fusion protein - ag19413 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

LRP4 fusion protein - ag19487 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human LRP4 - LRP4-688H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human LRP4 - LRP4-360H from Creative Biomart Category Protein Source CHO cells Species Human

Recombinant Low Density Lipoprotein Receptor Related Protein 4 (LRP4) - RPD747Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Low Density Lipoprotein Receptor Related Protein 4 (LRP4) - RPD747Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant human Low-density lipoprotein receptor-related protein 4 - CSB-YP013099HU CSB-BP013099HU CSB-MP013099HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Low-density lipoprotein receptor-related protein 4 - CSB-EP013099HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Viral MIP-I Protein - 600-VA from R&D Systems Category Protein Prices $329.00 Sizes 25 µg Source E. coli -derived Ala25-Ala95

Recombinant Human LRP-4 Protein, CF - 5948-LR from R&D Systems Category Protein Prices $319.00 Sizes 25 µg Source Chinese Hamster Ovary cell line, CHO-derived Human LRP-4 (Ser21-Ser1725) Accession # AAI36669 GGGSGGGSGGGS 6-His N-terminus C-terminus Species Human

LRP4/LRP10, Peptide - MBS425740 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Bovine

LRP-4 Recombinant Protein Antigen - NBP1-81241PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LRP-4 Recombinant Protein Antigen - NBP1-81240PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human Low-density lipoprotein receptor-related protein 4(LRP4) ,partial - CSB-YP013099HU from Cusabio Category Protein Source Yeast Species Human

Recombinant Human Low-density lipoprotein receptor-related protein 4(LRP4) ,partial - CSB-MP013099HU from Cusabio Category Protein Source Yeast Species Human

Recombinant Human Low-density lipoprotein receptor-related protein 4(LRP4) ,partial - CSB-BP013099HU from Cusabio Category Protein Source Yeast Species Human

LRP4-Antibody-C-term-Blocking-Peptide - BP6156a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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