| Gene Symbol |
CYP4A11
|
| Entrez Gene |
1579
|
| Alt Symbol |
CP4Y, CYP4A2, CYP4AII
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 4, subfamily A, polypeptide 11
|
| Other Description |
20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVA11|P450HL-omega|alkane-1 monooxygenase|cytochrome P-450HK-omega|cytochrome P450 4A11|cytochrome P450, subfamily IVA, polypeptide 11|cytochrome P450HL-omega|fatty acid omega-hydroxylase|lauric acid omega-hydroxylase
|
| Swissprots |
Q06766 Q8IWY5 Q16865 Q5VSP8 Q02928 Q86SU6 Q16866
|
| Accessions |
AAO16078 AAQ56847 Q02928 AK298267 BAG60530 AK298413 BAG60640 BC022851 BC041158 AAH41158 CD014132 D13705 BAA02864 D26481 BAA05491 L04751 AAA58436 S67580 AAB29502 S67581 AAB29503 X71480 CAA50586 XM_005270539 XP_005270596 XM_011540826 XP_011539128 XM_011540827 XP_011539129 XM_011540828 XP_011539130 XM_011540829 XP_011539131 XM_011540830 XP_011539132 XR_246241 XR_246242 NM_000778 NP_000769
|
| Function |
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). {ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:7679927}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Kidney and liver. {ECO:0000269|PubMed:7679927}.
|
| Top Pathways |
Vascular smooth muscle contraction, Arachidonic acid metabolism, Fatty acid degradation, Retinol metabolism
|