Gene Symbol | CYP4A11 |
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Entrez Gene | 1579 |
Alt Symbol | CP4Y, CYP4A2, CYP4AII |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 4, subfamily A, polypeptide 11 |
Other Description | 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVA11|P450HL-omega|alkane-1 monooxygenase|cytochrome P-450HK-omega|cytochrome P450 4A11|cytochrome P450, subfamily IVA, polypeptide 11|cytochrome P450HL-omega|fatty acid omega-hydroxylase|lauric acid omega-hydroxylase |
Swissprots | Q06766 Q8IWY5 Q16865 Q5VSP8 Q02928 Q86SU6 Q16866 |
Accessions | AAO16078 AAQ56847 Q02928 AK298267 BAG60530 AK298413 BAG60640 BC022851 BC041158 AAH41158 CD014132 D13705 BAA02864 D26481 BAA05491 L04751 AAA58436 S67580 AAB29502 S67581 AAB29503 X71480 CAA50586 XM_005270539 XP_005270596 XM_011540826 XP_011539128 XM_011540827 XP_011539129 XM_011540828 XP_011539130 XM_011540829 XP_011539131 XM_011540830 XP_011539132 XR_246241 XR_246242 NM_000778 NP_000769 |
Function | Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). {ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:7679927}. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Kidney and liver. {ECO:0000269|PubMed:7679927}. |
Top Pathways | Vascular smooth muscle contraction, Arachidonic acid metabolism, Fatty acid degradation, Retinol metabolism |
CYP4A11 (M25-P2A10) - sc-101385 from Santa Cruz Biotechnology
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CYP4A11 (N-14) - sc-323772 from Santa Cruz Biotechnology
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Anti-Cytochrome P450 4A antibody - ab3573 from Abcam
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Anti-Cytochrome P450 4A antibody - ab96853 from Abcam
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Anti-Cytochrome P450 4A antibody [EPR8276] - ab140635 from Abcam
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Anti-Cytochrome P450 4A antibody - C-terminal - ab82857 from Abcam
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Anti-Cytochrome P450 4A11/22 antibody - ab152000 from Abcam
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Anti-Cytochrome P450 4A11/22 antibody - ab110746 from Abcam
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Anti-CYP4A11 Antibody (aa431-445) - LS-C64211 from LifeSpan Bioscience
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Anti-CYP4A11 Antibody - LS-C341798 from LifeSpan Bioscience
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Anti-CYP4A11 Antibody (C-Terminus) - LS-C97499 from LifeSpan Bioscience
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Anti-CYP4A11 Antibody (aa48-316) - LS-C185545 from LifeSpan Bioscience
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Cytochrome P450 4A Antibody - NBP1-31427 from Novus Biologicals
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Cytochrome P450 4A Antibody - NBP2-16081 from Novus Biologicals
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Cytochrome P450 4A Antibody - H00001579-B01P from Novus Biologicals
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Cytochrome P450 4A Polyclonal Antibody - bs-5054R from Bioss
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Anti-CYP4A11 antibody produced in rabbit - SAB2702082 from Sigma-Aldrich
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Anti-CYP4A11 (4A22) (C-term) antibody produced in rabbit - SAB1300945 from Sigma-Aldrich
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Anti-CYP4A11 antibody produced in mouse - SAB1405690 from Sigma-Aldrich
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Anti-CYP4A11 (N-term) antibody produced in rabbit - SAB1300944 from Sigma-Aldrich
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CYP4A11-4A22-Antibody-C-term - AP7884b from Abgent, a WuXi AppTec company
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CYP4A11 Antibody - C-terminal region (OAAB04961) - OAAB04961 from Aviva Systems Biology
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CYP4A11 antibody [N1C1] - GTX103518 from GeneTex
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CYP4A11 antibody [N3C3] - GTX114353 from GeneTex
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Cytochrome P450 4A antibody - GTX79175 from GeneTex
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