Gene Symbol | CYP4A11 |
---|---|
Entrez Gene | 1579 |
Alt Symbol | CP4Y, CYP4A2, CYP4AII |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 4, subfamily A, polypeptide 11 |
Other Description | 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVA11|P450HL-omega|alkane-1 monooxygenase|cytochrome P-450HK-omega|cytochrome P450 4A11|cytochrome P450, subfamily IVA, polypeptide 11|cytochrome P450HL-omega|fatty acid omega-hydroxylase|lauric acid omega-hydroxylase |
Swissprots | Q06766 Q8IWY5 Q16865 Q5VSP8 Q02928 Q86SU6 Q16866 |
Accessions | AAO16078 AAQ56847 Q02928 AK298267 BAG60530 AK298413 BAG60640 BC022851 BC041158 AAH41158 CD014132 D13705 BAA02864 D26481 BAA05491 L04751 AAA58436 S67580 AAB29502 S67581 AAB29503 X71480 CAA50586 XM_005270539 XP_005270596 XM_011540826 XP_011539128 XM_011540827 XP_011539129 XM_011540828 XP_011539130 XM_011540829 XP_011539131 XM_011540830 XP_011539132 XR_246241 XR_246242 NM_000778 NP_000769 |
Function | Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). {ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:7679927}. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Kidney and liver. {ECO:0000269|PubMed:7679927}. |
Top Pathways | Vascular smooth muscle contraction, Arachidonic acid metabolism, Fatty acid degradation, Retinol metabolism |
CYP4A11 CRISPR/Cas9 KO Plasmid (h) - sc-407702 from Santa Cruz Biotechnology
|
||||||||
CYP4A11 HDR Plasmid (h) - sc-407702-HDR from Santa Cruz Biotechnology
|
||||||||
CYP4A11 Double Nickase Plasmid (h) - sc-407702-NIC from Santa Cruz Biotechnology
|
||||||||
CYP4A11 Double Nickase Plasmid (h2) - sc-407702-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CYP4A11 CRISPR Activation Plasmid (h) - sc-407702-ACT from Santa Cruz Biotechnology
|
||||||||
CYP4A11 CRISPR Activation Plasmid (h2) - sc-407702-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CYP4A11 Lentiviral Activation Particles (h) - sc-407702-LAC from Santa Cruz Biotechnology
|
||||||||
CYP4A11 Lentiviral Activation Particles (h2) - sc-407702-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CYP4A11 siRNA (h) - sc-88588 from Santa Cruz Biotechnology
|
||||||||
CYP4A11 shRNA Plasmid (h) - sc-88588-SH from Santa Cruz Biotechnology
|
||||||||
CYP4A11 shRNA (h) Lentiviral Particles - sc-88588-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU127581 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1806 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1806 from Sigma-Aldrich
|
||||||||
CYP4A11 siRNA (Human) - CRH1108 from Cohesion Biosciences
|
||||||||
Cytochrome P450 4A RNAi - H00001579-R01 from Novus Biologicals
|
||||||||
CYP4A11 - MBS8202346 from MyBioSource
|
||||||||
shRNA set against Human Cyp4a1 (NM_000778.3) - SHH273545 from Creative biogene
|
||||||||
shRNA set against Human CYP4A11(NM_000778.3) - SHG207287 from Creative biogene
|
||||||||
Human CYP4A11 siRNA - orb261610 from Biorbyt
|
||||||||
CYP4A11 shRNA Plasmid (Human) - CHH1108 from Cohesion Biosciences
|
||||||||
CYP4A11 miRNA 3'UTR clone - MiUTR1H-02636 from Creative biogene
|