| Gene Symbol |
TAB3
|
| Entrez Gene |
257397
|
| Alt Symbol |
MAP3K7IP3, NAP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TGF-beta activated kinase 1/MAP3K7 binding protein 3
|
| Other Description |
NF-kappa-B-activating protein 1|NFkB activating protein 1|TAB-3|TAK1-binding protein 3|TGF-beta-activated kinase 1 and MAP3K7-binding protein 3|TGF-beta-activated kinase 1-binding protein 3|mitogen-activated protein kinase kinase kinase 7 interacting protein 3
|
| Swissprots |
Q6VQR0 A6NDD9 Q8N5C8
|
| Accessions |
EAW99057 EAW99058 EAW99059 Q8N5C8 AK096786 AK297274 BAG59746 AL832071 CAI46137 AY331591 AAQ92938 AY331592 AAQ92939 AY371491 AAQ88279 AY437560 AAR06179 BC032526 AAH32526 BU849692 DA494641 XM_005274482 XP_005274539 XM_005274483 XP_005274540 XM_005274484 XP_005274541 XM_011545487 XP_011543789 XM_011545488 XP_011543790 XR_430492 XR_950433 XR_950434 XR_950435 NM_152787 NP_690000 NM_198312
|
| Function |
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965}.
|
| Tissue Specificity |
Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript. {ECO:0000269|PubMed:14670075, ECO:0000269|PubMed:14766965}.
|
| Top Pathways |
NOD-like receptor signaling pathway, TNF signaling pathway
|