Gene Symbol | TAB3 |
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Entrez Gene | 257397 |
Alt Symbol | MAP3K7IP3, NAP1 |
Species | Human |
Gene Type | protein-coding |
Description | TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
Other Description | NF-kappa-B-activating protein 1|NFkB activating protein 1|TAB-3|TAK1-binding protein 3|TGF-beta-activated kinase 1 and MAP3K7-binding protein 3|TGF-beta-activated kinase 1-binding protein 3|mitogen-activated protein kinase kinase kinase 7 interacting protein 3 |
Swissprots | Q6VQR0 A6NDD9 Q8N5C8 |
Accessions | EAW99057 EAW99058 EAW99059 Q8N5C8 AK096786 AK297274 BAG59746 AL832071 CAI46137 AY331591 AAQ92938 AY331592 AAQ92939 AY371491 AAQ88279 AY437560 AAR06179 BC032526 AAH32526 BU849692 DA494641 XM_005274482 XP_005274539 XM_005274483 XP_005274540 XM_005274484 XP_005274541 XM_011545487 XP_011543789 XM_011545488 XP_011543790 XR_430492 XR_950433 XR_950434 XR_950435 NM_152787 NP_690000 NM_198312 |
Function | Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965}. |
Tissue Specificity | Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript. {ECO:0000269|PubMed:14670075, ECO:0000269|PubMed:14766965}. |
Top Pathways | NOD-like receptor signaling pathway, TNF signaling pathway |
SignalSilence ® TAB3 siRNA II - 14225 from Cell Signaling Technology
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SignalSilence ® TAB3 siRNA I - 14212 from Cell Signaling Technology
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TAB3 CRISPR/Cas9 KO Plasmid (h) - sc-404049 from Santa Cruz Biotechnology
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TAB3 HDR Plasmid (h) - sc-404049-HDR from Santa Cruz Biotechnology
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TAB3 Double Nickase Plasmid (h) - sc-404049-NIC from Santa Cruz Biotechnology
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TAB3 Double Nickase Plasmid (h2) - sc-404049-NIC-2 from Santa Cruz Biotechnology
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TAB3 CRISPR Activation Plasmid (h) - sc-404049-ACT from Santa Cruz Biotechnology
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TAB3 CRISPR Activation Plasmid (h2) - sc-404049-ACT-2 from Santa Cruz Biotechnology
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TAB3 Lentiviral Activation Particles (h) - sc-404049-LAC from Santa Cruz Biotechnology
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TAB3 Lentiviral Activation Particles (h2) - sc-404049-LAC-2 from Santa Cruz Biotechnology
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TAB3 siRNA (h) - sc-43548 from Santa Cruz Biotechnology
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TAB3 shRNA Plasmid (h) - sc-43548-SH from Santa Cruz Biotechnology
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TAB3 shRNA (h) Lentiviral Particles - sc-43548-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU120321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20945 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20945 from Sigma-Aldrich
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TAB3 siRNA (Human) - CRJ6792 from Cohesion Biosciences
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TAB3 - MBS8223321 from MyBioSource
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shRNA set against Human TAB3 (NM_152787.3) - SHH422372 from Creative biogene
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shRNA set against Human MAP3K7IP3(NM_152787.3) - SHH174485 from Creative biogene
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TAB3 shRNA Plasmid (Human) - CHJ6792 from Cohesion Biosciences
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TAB3 miRNA 3'UTR clone - MiUTR1H-06068 from Creative biogene
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