Gene Symbol | Nr1h4 |
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Entrez Gene | 20186 |
Alt Symbol | AI957360, Fxr, HRR1, RIP14, Rxrip14 |
Species | Mouse |
Gene Type | protein-coding |
Description | nuclear receptor subfamily 1, group H, member 4 |
Other Description | RXR-interacting protein 14|bile acid receptor|farnesoid X activated receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14 |
Swissprots | Q60642 Q60643 E9QJW2 Q60641 |
Accessions | AAK15460 AAQ73843 AAQ73844 EDL21500 EDL21501 EDL21502 Q60641 AK002513 AK050566 AK132255 BAE21061 BC015261 AAH15261 U09416 AAC53066 U09417 AAC53065 U09418 AAC52978 XM_006513391 XP_006513454 XM_006513393 XP_006513456 NM_001163504 NP_001156976 NM_001163700 NP_001157172 NM_009108 NP_033134 |
Function | Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expressed specifically in liver and kidney. |
Top Pathways | Bile secretion |
Bile acid receptor (NR1H4), Mouse, ELISA Kit - E03B0957 from ARP American Research Products
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Bile acid receptor, Nr1h4, Mouse, ELISA Kit - E2042m from ARP American Research Products
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Farnesoid X Receptor (FXR), Mouse, ELISA Kit - SEC042Mu from ARP American Research Products
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Nuclear receptor subfamily 1, group H, member 4 (NR1H4), Mouse, ELISA Kit - E03N0563 from ARP American Research Products
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Mouse FXR ELISA Kit - MF0272 from NeoScientific
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nuclear receptor subfamily 1, group H, member 4 (NR1H4), ELISA Kit - MBS7202120 from MyBioSource
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ELISA Kit for Farnesoid X Receptor (FXR) - SEC042Mu from Cloud-clone
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Mouse FXR ELISA Kit - abx571018 from Abbexa
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Mouse Nr1h4 ELISA Kit - E045850 from Biobool
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Mouse FXR ELISA Kit - E052684 from Biobool
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Mouse FXR ELISA Kit - EMF0272 from ABclonal
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Bile acid receptor, ELISA Kit - MBS2880847 from MyBioSource
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Farnesoid X Receptor (FXR), ELISA Kit - MBS450788 from MyBioSource
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