Nr1h4

Gene Symbol Nr1h4
Entrez Gene 20186
Alt Symbol AI957360, Fxr, HRR1, RIP14, Rxrip14
Species Mouse
Gene Type protein-coding
Description nuclear receptor subfamily 1, group H, member 4
Other Description RXR-interacting protein 14|bile acid receptor|farnesoid X activated receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14
Swissprots Q60642 Q60643 E9QJW2 Q60641
Accessions AAK15460 AAQ73843 AAQ73844 EDL21500 EDL21501 EDL21502 Q60641 AK002513 AK050566 AK132255 BAE21061 BC015261 AAH15261 U09416 AAC53066 U09417 AAC53065 U09418 AAC52978 XM_006513391 XP_006513454 XM_006513393 XP_006513456 NM_001163504 NP_001156976 NM_001163700 NP_001157172 NM_009108 NP_033134
Function Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Expressed specifically in liver and kidney.
Top Pathways Bile secretion

FXR CRISPR/Cas9 KO Plasmid (m) - sc-422772 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FXR HDR Plasmid (m) - sc-422772-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FXR Double Nickase Plasmid (m) - sc-422772-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FXR Double Nickase Plasmid (m2) - sc-422772-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FXR CRISPR Activation Plasmid (m) - sc-422772-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FXR CRISPR Activation Plasmid (m2) - sc-422772-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FXR Lentiviral Activation Particles (m) - sc-422772-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FXR Lentiviral Activation Particles (m2) - sc-422772-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FXR siRNA (m) - sc-155894 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

FXR shRNA Plasmid (m) - sc-155894-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

FXR shRNA (m) Lentiviral Particles - sc-155894-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU026301 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN36651 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36651 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NR1H4 siRNA (Mouse) - CRM3569 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse NR1H4 (NM_009108.2) - SHH354688 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Nr1h4(NM_001163504.1) - SHR019968 from Creative biogene

Category siRNA
Species Reactivities Mouse

NR1H4 shRNA Plasmid (Mouse) - CHM3569 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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