DPPA3

Gene Symbol DPPA3
Entrez Gene 359787
Alt Symbol STELLA
Species Human
Gene Type protein-coding
Description developmental pluripotency associated 3
Other Description developmental pluripotency-associated protein 3|stella-related protein
Swissprots Q0P5U3 Q6JZS6 Q6W0C5
Accessions EAW88657 EAW88658 Q6W0C5 AY317075 AAQ84110 BC160067 AAI60067 NM_199286 NP_954980
Function Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. A
Subcellular Location Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker. {ECO:0000250}.
Tissue Specificity Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells. Highly expressed in testicular germ cell tumors. {ECO:0000269|PubMed:14654002, ECO:0000269|PubMed:14684992, ECO:0000269|PubMed:14990856}.

Human DPPA3 cDNA clone(NM_199286.2) - CDFG013114 from Creative Biomart

Species Human
Accession NM_199286.2

Human DPPA3 ORF Clone(NM_199286.2) - CDCL161491 from Creative Biomart

Species Human
Accession NM_199286.2

Human DPPA3 ORF Clone(NM_199286.2) - CDCR326663 from Creative Biomart

Species Human
Accession NM_199286.2

Human DPPA3 ORF Clone(NM_199286.2) - CDCR326664 from Creative Biomart

Species Human
Accession NM_199286.2

Human DPPA3 ORF Clone(NM_199286.2) - CDCR326665 from Creative Biomart

Species Human
Accession NM_199286.2

Human DPPA3 ORF Clone(NM_199286.2) - CDCR326663 from Creative biogene

Species Human

Human DPPA3 cDNA Clone(NM_199286.2) - CDFG013114 from Creative biogene

Species Human
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