DPPA3

Gene Symbol	DPPA3
Entrez Gene	359787
Alt Symbol	STELLA
Species	Human
Gene Type	protein-coding
Description	developmental pluripotency associated 3
Other Description	developmental pluripotency-associated protein 3|stella-related protein
Swissprots	Q0P5U3 Q6JZS6 Q6W0C5
Accessions	EAW88657 EAW88658 Q6W0C5 AY317075 AAQ84110 BC160067 AAI60067 NM_199286 NP_954980
Function	Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. A
Subcellular Location	Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker. {ECO:0000250}.
Tissue Specificity	Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells. Highly expressed in testicular germ cell tumors. {ECO:0000269|PubMed:14654002, ECO:0000269|PubMed:14684992, ECO:0000269|PubMed:14990856}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Stella full length protein - ab134623 from Abcam Category Protein Source E. coli Species Human

Mouse Stella peptide - ab23324 from Abcam Category Peptide

DPPA3 / STELLA Antibody Blocking Peptide - LS-E26055 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DPPA3 / STELLA Antibody Blocking Peptide - LS-E30553 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Stella/Dppa3 Protein - NBP2-22997 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

Stella Peptide - GTX85384-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Human DPPA3 protein - orb168247 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

DPPA3 protein (His tag) - 80R-2488 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

STELLAR / DPPA3 (1-159, His-tag) - AR50560PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

STELLAR / DPPA3 (1-159, His-tag) - AR50560PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

STELLAR / DPPA3 Control Peptide - AP30836CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DPPA3, 1-159aa, Human, His tag, E.coli - 01-P1736 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Stella Peptide - 4755P from ProSci Category Peptide Species Human

STELLAR Peptide - 46-444P from ProSci Category Peptide

DPPA3 Human - PRPS-1298 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

DPPA3, 1-159aa, Recombinant Protein - GWB-P0302C from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant Human Developmental Pluripotency Associated 3, His-tagged - DPPA3-7168H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Developmental pluripotency-associated protein 3(DPPA3) - CSB-YP744290HU CSB-EP744290HU CSB-BP744290HU CSB-MP744290HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DPPA3, 1-159aa, Human, His tag, E.coli (Denatured) - ATGP1736 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

STELLAR, Peptide - MBS426277 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Developmental Pluripotency Associated Protein 3 (DPPA3) - RPC433Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Developmental Pluripotency Associated Protein 3 (DPPA3) - RPC433Hu01 from Cloud-clone Category Protein Source E.coli Species Human

DPPA3 Protein - NBP2-33448PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Developmental Pluripotency Associated 3 Protein (Recombinant) - abx262563 from Abbexa Category Protein

DPPA3-Blocking-Peptide-C-term - BP21453b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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