CCDC22

Gene Symbol CCDC22
Entrez Gene 28952
Alt Symbol CXorf37, JM1
Species Human
Gene Type protein-coding
Description coiled-coil domain containing 22
Other Description coiled-coil domain-containing protein 22
Swissprots O60826 A8K7G1
Accessions EAW50674 EAW50675 EAW50676 O60826 AJ005890 CAA06747 AK291976 BAF84665 AK296911 BAG59466 AK298264 BAG60528 AK316375 BAH14746 BC000972 AAH00972 BC011675 AAH11675 BG912845 BM146102 DC340647 DQ894170 ABM85096 EU176573 ABW03374 XM_005272599 XP_005272656 XR_430506 NM_014008 NP_054727
Function Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF- kappa-B activity via assocation with COMMD1 and involving a CUL2- dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). {ECO:0000269|PubMed:23563313, ECO:0000269|PubMed:25355947}.
Subcellular Location Endosome {ECO:0000305}.
Tissue Specificity Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle. {ECO:0000269|PubMed:21826058}.

CCDC22 (E-15) - sc-161439 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CCDC22 antibody - ab139948 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of CCDC22 in Human brain tissue with ab139948 at 20 ug/mL.

Anti-CCDC22 antibody - ab115982 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CCDC22 antibody (ab115982) at 1/100 dilution + WiDr cell line lysates at 35 µg

Anti-CCDC22 Antibody (N-Terminus) IHC-plus™ - LS-B8841 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCDC22 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CCDC22 Antibody (aa530-558, AP) - LS-C253637 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC22 Antibody (aa530-558, Biotin) - LS-C253639 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC22 Antibody (aa530-558, FITC) - LS-C253640 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC22 Antibody (aa530-558, APC) - LS-C253638 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC22 Antibody (aa530-558, Azide-free, HRP) - LS-C253641 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC22 Antibody (aa530-558, PE) - LS-C253643 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC22 Antibody (aa529-558) - LS-C320065 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCDC22 Antibody (aa530-558) - LS-C168411 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CCDC22 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

CCDC22 Antibody - NBP1-84331 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CCDC22 Antibody [NBP1-84331] - Lane 1: Marker [kDa] 219, 112, 85, 49, 32, 25, 18. Lane 2: Human cell line RT-4

CCDC22 Polyclonal Antibody - bs-8124R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-CCDC22 (C-TERM) antibody produced in rabbit - SAB1304632 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>CCDC22 (C-term): <B>Cat. No. SAB1304632</B>: CCDC22 in Human stomach tissue with CCDC22 antibody (C-term) at 10 μg/mL.

Anti-CCDC22 antibody produced in rabbit - HPA000888 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CCDC22: <B>Cat. No. HPA000888</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human stomach tissue showing cytoplasmic staining of parietal cells.

Anti-CCDC22 antibody produced in rabbit - SAB3500803 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>CCDC22 Antibody: <B>Cat. No. SAB3500803</B>: Western blot analysis of CCDC22 in 293 cell lysate with CCDC22 antibody at (A) 1 and (B) 2 μg/mL.

CCDC22-Antibody-C-term - AP13480b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
CCDC22 Antibody (C-term) (Cat. #AP13480b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the CCDC22 antibody detected the CCDC22 protein (arrow).

CCDC22 Antibody - C-terminal region (OAAB09774) - OAAB09774 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CCDC22 antibody - orb75819 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of 293 cell lysate at (A) 1 and (B) 2 ug/mL using CCDC22 antibody

CCDC22 antibody - 70R-16208 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti -CCDC22 (Coiled-coil Domain-containing Protein 22, JM1, CXorf37) - 209927 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -CCDC22 (Coiled-coil domain-containing protein 22, JM1, CXorf37) - 167786 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -CCDC22, CT (CCDC22, CXorf37, Coiled-coil domain-containing protein 22) - 033314 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -CCDC22, CT (CCDC22, CXorf37, Coiled-coil domain-containing protein 22) (AP) - 033314-AP from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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