| Gene Symbol | CCDC22 |
|---|---|
| Entrez Gene | 28952 |
| Alt Symbol | CXorf37, JM1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | coiled-coil domain containing 22 |
| Other Description | coiled-coil domain-containing protein 22 |
| Swissprots | O60826 A8K7G1 |
| Accessions | EAW50674 EAW50675 EAW50676 O60826 AJ005890 CAA06747 AK291976 BAF84665 AK296911 BAG59466 AK298264 BAG60528 AK316375 BAH14746 BC000972 AAH00972 BC011675 AAH11675 BG912845 BM146102 DC340647 DQ894170 ABM85096 EU176573 ABW03374 XM_005272599 XP_005272656 XR_430506 NM_014008 NP_054727 |
| Function | Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF- kappa-B activity via assocation with COMMD1 and involving a CUL2- dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). {ECO:0000269|PubMed:23563313, ECO:0000269|PubMed:25355947}. |
| Subcellular Location | Endosome {ECO:0000305}. |
| Tissue Specificity | Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle. {ECO:0000269|PubMed:21826058}. |