CCDC22

Gene Symbol	CCDC22
Entrez Gene	28952
Alt Symbol	CXorf37, JM1
Species	Human
Gene Type	protein-coding
Description	coiled-coil domain containing 22
Other Description	coiled-coil domain-containing protein 22
Swissprots	O60826 A8K7G1
Accessions	EAW50674 EAW50675 EAW50676 O60826 AJ005890 CAA06747 AK291976 BAF84665 AK296911 BAG59466 AK298264 BAG60528 AK316375 BAH14746 BC000972 AAH00972 BC011675 AAH11675 BG912845 BM146102 DC340647 DQ894170 ABM85096 EU176573 ABW03374 XM_005272599 XP_005272656 XR_430506 NM_014008 NP_054727
Function	Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF- kappa-B activity via assocation with COMMD1 and involving a CUL2- dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). {ECO:0000269|PubMed:23563313, ECO:0000269|PubMed:25355947}.
Subcellular Location	Endosome {ECO:0000305}.
Tissue Specificity	Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle. {ECO:0000269|PubMed:21826058}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CCDC22 Antibody Blocking Peptide - LS-E2458 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCDC22 Antibody Blocking Peptide - LS-E31298 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCDC22-Antibody-C-term-Blocking-peptide - BP13480b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CCDC22 (N-term) Control Peptide - AP55439CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CCDC22 Peptide - 6933P from ProSci Category Peptide Species Human

CCDC22 fusion protein - Ag9980 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CCDC22, GST-tagged - CCDC22-10795H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CCDC22 - CCDC22-441H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Coiled-coil domain-containing protein 22(CCDC22) - CSB-YP004681HU CSB-EP004681HU CSB-BP004681HU CSB-MP004681HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CCDC22 Protein - NBP1-84331PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

CCDC22 Peptide, Human - M34GP02528H from Creative Peptides Category Peptide Source Synthetic. Species Human

Coiled-coil domain-containing protein 22 (CCDC22), Recombinant Protein - MBS1184485 from MyBioSource Category Protein Prices $1,425.00, $1,425.00, $1,650.00, $1,650.00, $2,410.00, $2,410.00, $2,850.00, $2,850.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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