CCDC22

Gene Symbol CCDC22
Entrez Gene 28952
Alt Symbol CXorf37, JM1
Species Human
Gene Type protein-coding
Description coiled-coil domain containing 22
Other Description coiled-coil domain-containing protein 22
Swissprots O60826 A8K7G1
Accessions EAW50674 EAW50675 EAW50676 O60826 AJ005890 CAA06747 AK291976 BAF84665 AK296911 BAG59466 AK298264 BAG60528 AK316375 BAH14746 BC000972 AAH00972 BC011675 AAH11675 BG912845 BM146102 DC340647 DQ894170 ABM85096 EU176573 ABW03374 XM_005272599 XP_005272656 XR_430506 NM_014008 NP_054727
Function Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF- kappa-B activity via assocation with COMMD1 and involving a CUL2- dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). {ECO:0000269|PubMed:23563313, ECO:0000269|PubMed:25355947}.
Subcellular Location Endosome {ECO:0000305}.
Tissue Specificity Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle. {ECO:0000269|PubMed:21826058}.

CCDC22 CRISPR/Cas9 KO Plasmid (h) - sc-412004 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC22 HDR Plasmid (h) - sc-412004-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC22 Double Nickase Plasmid (h) - sc-412004-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC22 Double Nickase Plasmid (h2) - sc-412004-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC22 CRISPR Activation Plasmid (h) - sc-412004-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC22 CRISPR Activation Plasmid (h2) - sc-412004-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC22 Lentiviral Activation Particles (h) - sc-412004-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC22 Lentiviral Activation Particles (h2) - sc-412004-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC22 siRNA (h) - sc-91292 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCDC22 shRNA Plasmid (h) - sc-91292-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCDC22 shRNA (h) Lentiviral Particles - sc-91292-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU036471 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5510 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5510 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05911 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05911

CCDC22 siRNA (Human) - CRH9122 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCDC22 - MBS8234031 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human CCDC22 siRNA - orb269624 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCDC22 shRNA Plasmid (Human) - CHH9122 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CCDC22 miRNA 3'UTR clone - MiUTR3H-02950 from Creative biogene

Species Reactivities Human
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