TRA2B

Gene Symbol TRA2B
Entrez Gene 6434
Alt Symbol Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B
Species Human
Gene Type protein-coding
Description transformer 2 beta homolog (Drosophila)
Other Description TRA-2 beta|protein phosphatase 1, regulatory subunit 156|splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)|transformer-2 protein homolog B|transformer-2 protein homolog beta
Swissprots D3DNU3 B4DVK2 P62995
Accessions AAD19277 AAD19278 AAD19279 EAW78204 EAW78205 EAW78206 EAW78207 EAW78208 P62995 AB209208 BAD92445 AK091863 AK094495 AK098191 BAC05256 AK125610 AK301118 BAG62714 AK308267 AK315632 BAG38000 BC000160 AAH00160 BC000451 AAH00451 BC005898 AAH05898 CR749214 CAH18071 DA164444 DQ890937 ABM81863 EU176532 ABW03333 U61267 AAC28242 U68063 AAB08701 U87836 AAB69763 XM_005247703 XP_005247760 XM_006713724 XP_006713787 XM_011513072 XP_011511374 NM_001243879 NP_001230808 NM_004593 NP_004584
Function Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}.
Subcellular Location Nucleus {ECO:0000269|PubMed:9212162, ECO:0000269|PubMed:9546399}.
Tissue Specificity Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver. {ECO:0000269|PubMed:9790768}.
Top Pathways Spliceosome

TRA2B 293 Cell Lysate - 401323 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Species Drosophila

Tra-2 (h2): 293T Lysate - sc-176571 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

TRA2B Over-expression Lysate Product - GWB-4E65BE from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

TRA2B Overexpression Lysate (Native) - NBL1-15887 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: TRA2B Overexpression Lysate (Adult Normal) [NBL1-15887] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TRA2B.

Panoply™ Human TRA2B Knockdown Stable Cell Line - CSC-DC016508 from Creative biogene

Category Cell Line
Species Human
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