TRA2B

Gene Symbol	TRA2B
Entrez Gene	6434
Alt Symbol	Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B
Species	Human
Gene Type	protein-coding
Description	transformer 2 beta homolog (Drosophila)
Other Description	TRA-2 beta|protein phosphatase 1, regulatory subunit 156|splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)|transformer-2 protein homolog B|transformer-2 protein homolog beta
Swissprots	D3DNU3 B4DVK2 P62995
Accessions	AAD19277 AAD19278 AAD19279 EAW78204 EAW78205 EAW78206 EAW78207 EAW78208 P62995 AB209208 BAD92445 AK091863 AK094495 AK098191 BAC05256 AK125610 AK301118 BAG62714 AK308267 AK315632 BAG38000 BC000160 AAH00160 BC000451 AAH00451 BC005898 AAH05898 CR749214 CAH18071 DA164444 DQ890937 ABM81863 EU176532 ABW03333 U61267 AAC28242 U68063 AAB08701 U87836 AAB69763 XM_005247703 XP_005247760 XM_006713724 XP_006713787 XM_011513072 XP_011511374 NM_001243879 NP_001230808 NM_004593 NP_004584
Function	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9212162, ECO:0000269|PubMed:9546399}.
Tissue Specificity	Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver. {ECO:0000269|PubMed:9790768}.
Top Pathways	Spliceosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Tra-2 CRISPR/Cas9 KO Plasmid (h) - sc-404739 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tra-2 HDR Plasmid (h) - sc-404739-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tra-2 Double Nickase Plasmid (h) - sc-404739-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tra-2 Double Nickase Plasmid (h2) - sc-404739-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tra-2 CRISPR Activation Plasmid (h) - sc-404739-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tra-2 CRISPR Activation Plasmid (h2) - sc-404739-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tra-2 Lentiviral Activation Particles (h) - sc-404739-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tra-2 Lentiviral Activation Particles (h2) - sc-404739-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tra-2β siRNA (h) - sc-38566 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tra-2β shRNA Plasmid (h) - sc-38566-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tra-2β shRNA (h) Lentiviral Particles - sc-38566-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TRA2B RNAi - H00006434-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TRA2B RNAi - H00006434-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU095031 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU091931 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN21900 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21900 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

TRA2B siRNA (Human) - CRH4349 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TRA2B - MBS8204048 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TRA2B (NM_004593.2) - SHH433644 from Creative biogene Category siRNA Species Reactivities Human

Human TRA2B siRNA - orb264851 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TRA2B shRNA Plasmid (Human) - CHH4349 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TRA2B miRNA 3'UTR clone - MiUTR4H-TG09299 from Creative biogene Species Reactivities Human

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