Gene Symbol | CLEC12A |
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Entrez Gene | 160364 |
Alt Symbol | CLL-1, CLL1, DCAL-2, MICL |
Species | Human |
Gene Type | protein-coding |
Description | C-type lectin domain family 12, member A |
Other Description | C-type lectin domain family 12 member A|C-type lectin protein CLL-1|C-type lectin-like molecule-1|dendritic cell-associated lectin 2|myeloid inhibitory C-type lectin-like receptor |
Swissprots | Q6P4H1 B2RA16 Q6RH77 Q6RH78 Q8TDQ6 Q5QGZ9 |
Accessions | CAI45358 CBX47387 EAW96132 EAW96133 Q5QGZ9 AF247788 AAL95693 AK314001 BAG36713 AY426759 AAR84594 AY498550 AAS00605 AY498551 AAS00606 AY498552 AAS00607 AY547296 AAT11783 BC027967 BC063424 AAH63424 BC126289 AAI26290 BC126291 AAI26292 BE242761 BQ017053 CD642076 XM_005253324 XP_005253381 XM_006719033 XP_006719096 XM_006719035 XP_006719098 XM_006719036 XP_006719099 XM_011520570 XP_011518872 XM_011520571 XP_011518873 XM_011520572 XP_011518874 XM_011520573 XP_011518875 NM_001207010 NP_001193939 NM_001300730 NP_001287659 NM_138337 NP_612210 NM_201623 NP_963917 NM_201625 |
Function | Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:16239426}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}; Single-pass type II membrane protein {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}. Note=Ligand binding leads to internalization. |
Tissue Specificity | Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages. {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}. |
CLEC-12A (F-12) - sc-109517 from Santa Cruz Biotechnology
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Anti-CLEC12A antibody - ab107494 from Abcam
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Anti-CLEC12A antibody - C-terminal - ab193941 from Abcam
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Anti-CLEC12A Antibody (aa185-214, APC) - LS-C221811 from LifeSpan Bioscience
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Anti-CLEC12A Antibody (aa185-214, Biotin) - LS-C221812 from LifeSpan Bioscience
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Anti-CLEC12A Antibody (aa185-214, FITC) - LS-C221814 from LifeSpan Bioscience
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Anti-CLEC12A Antibody (aa185-214, Azide-free, HRP) - LS-C221816 from LifeSpan Bioscience
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Anti-CLEC12A Antibody (aa185-214) - LS-C320432 from LifeSpan Bioscience
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Anti-CLEC12A Antibody - LS-C341994 from LifeSpan Bioscience
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Anti-CLEC12A Antibody (aa185-214) - LS-C168828 from LifeSpan Bioscience
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Anti-CLEC12A Antibody - LS-C334585 from LifeSpan Bioscience
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Anti-CLEC12A Antibody (aa185-214, PE) - LS-C221815 from LifeSpan Bioscience
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Anti-CLEC12A Antibody (aa67-267, PE) - LS-C182821 from LifeSpan Bioscience
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Anti-CLEC12A Antibody (aa185-214, AP) - LS-C221809 from LifeSpan Bioscience
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MICL/CLEC12A Antibody - NBP2-27346 from Novus Biologicals
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MICL/CLEC12A Antibody - NBP2-13843 from Novus Biologicals
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MICL/CLEC12A Antibody - AF2946 from Novus Biologicals
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MICL/CLEC12A Antibody (687317) [Unconjugated] - MAB2946 from Novus Biologicals
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MICL/CLEC12A Antibody (687317) [Allophycocyanin] - FAB2946A from Novus Biologicals
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MICL/CLEC12A Antibody (687317) [Alexa Fluor 700] - FAB2946N from Novus Biologicals
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MICL/CLEC12A Antibody (687317) [Alexa Fluor 488] - FAB2946G from Novus Biologicals
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MICL/CLEC12A Antibody (687317) [Phycoerythrin] - FAB2946P from Novus Biologicals
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MICL/CLEC12A Antibody (687317) [PerCP (Peridinin-chlorophyll Protein Complex)] - FAB2946C from Novus Biologicals
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MICL/CLEC12A Antibody [Biotin] - BAF2946 from Novus Biologicals
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CLEC12A Polyclonal Antibody - bs-13628R from Bioss
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