Gene Symbol | CLEC12A |
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Entrez Gene | 160364 |
Alt Symbol | CLL-1, CLL1, DCAL-2, MICL |
Species | Human |
Gene Type | protein-coding |
Description | C-type lectin domain family 12, member A |
Other Description | C-type lectin domain family 12 member A|C-type lectin protein CLL-1|C-type lectin-like molecule-1|dendritic cell-associated lectin 2|myeloid inhibitory C-type lectin-like receptor |
Swissprots | Q6P4H1 B2RA16 Q6RH77 Q6RH78 Q8TDQ6 Q5QGZ9 |
Accessions | CAI45358 CBX47387 EAW96132 EAW96133 Q5QGZ9 AF247788 AAL95693 AK314001 BAG36713 AY426759 AAR84594 AY498550 AAS00605 AY498551 AAS00606 AY498552 AAS00607 AY547296 AAT11783 BC027967 BC063424 AAH63424 BC126289 AAI26290 BC126291 AAI26292 BE242761 BQ017053 CD642076 XM_005253324 XP_005253381 XM_006719033 XP_006719096 XM_006719035 XP_006719098 XM_006719036 XP_006719099 XM_011520570 XP_011518872 XM_011520571 XP_011518873 XM_011520572 XP_011518874 XM_011520573 XP_011518875 NM_001207010 NP_001193939 NM_001300730 NP_001287659 NM_138337 NP_612210 NM_201623 NP_963917 NM_201625 |
Function | Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:16239426}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}; Single-pass type II membrane protein {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}. Note=Ligand binding leads to internalization. |
Tissue Specificity | Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages. {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}. |
CLEC12A Antibody Blocking Peptide - LS-E18 from LifeSpan Bioscience
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Recombinant Human MICL/CLEC12A Protein - H00160364-G01-10ug from Novus Biologicals
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CLEC12A-Antibody-Center-Blocking-peptide - BP10037c from Abgent, a WuXi AppTec company
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Human CLEC12A His tag protein - orb84403 from Biorbyt
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CLEC12A - H00160364-Q01-10 from Acris Antibodies
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CLEC12A - H00160364-Q01-25 from Acris Antibodies
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CLEC12A fusion protein - ag6379 from Proteintech Group
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Recombinant Human CLEC12A, His tagged - CLEC12A-6910H from Creative Biomart
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CLEC12A - PN201332 from Elabscience
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Human CLEC12A / CLL-1 / DCAL2 Protein (His Tag) - 11896-H07H-10 from Sino Biological
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Recombinant Human C-type lectin domain family 12 member A(CLEC12A) - CSB-YP725176HU CSB-EP725176HU CSB-BP725176HU CSB-MP725176HU from Cusabio
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C-type lectin domain family 12 member A (CLEC12A), Recombinant Protein - MBS1294751 from MyBioSource
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CLEC12A/MICL, Peptide - MBS428048 from MyBioSource
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Recombinant Human CLEC12A / CLL-1 / DCAL2 Protein (His tag) - PKSH030977 from Elabscience
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MICL/CLEC12A Recombinant Protein Antigen - NBP2-13843PEP from Novus Biologicals
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CLEC12A Peptide, Human - M34GP03250H from Creative Peptides
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Human CLEC12A / CLL-1 / DCAL2 Protein (His Tag) - 11896-H07H-50 from Sino Biological
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Human CLEC12A / CLL-1 / DCAL2 Protein (His Tag) - 11896-H07H from ABclonal
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Recombinant Human CLL-1 - 230-20202-200 from RayBiotech
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CLEC12A / CLL-1 / DCAL2, Recombinant Protein - MBS2545643 from MyBioSource
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CLEC12A fusion protein - Ag27864 from Proteintech Group
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