| Gene Symbol |
CLEC12A
|
| Entrez Gene |
160364
|
| Alt Symbol |
CLL-1, CLL1, DCAL-2, MICL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C-type lectin domain family 12, member A
|
| Other Description |
C-type lectin domain family 12 member A|C-type lectin protein CLL-1|C-type lectin-like molecule-1|dendritic cell-associated lectin 2|myeloid inhibitory C-type lectin-like receptor
|
| Swissprots |
Q6P4H1 B2RA16 Q6RH77 Q6RH78 Q8TDQ6 Q5QGZ9
|
| Accessions |
CAI45358 CBX47387 EAW96132 EAW96133 Q5QGZ9 AF247788 AAL95693 AK314001 BAG36713 AY426759 AAR84594 AY498550 AAS00605 AY498551 AAS00606 AY498552 AAS00607 AY547296 AAT11783 BC027967 BC063424 AAH63424 BC126289 AAI26290 BC126291 AAI26292 BE242761 BQ017053 CD642076 XM_005253324 XP_005253381 XM_006719033 XP_006719096 XM_006719035 XP_006719098 XM_006719036 XP_006719099 XM_011520570 XP_011518872 XM_011520571 XP_011518873 XM_011520572 XP_011518874 XM_011520573 XP_011518875 NM_001207010 NP_001193939 NM_001300730 NP_001287659 NM_138337 NP_612210 NM_201623 NP_963917 NM_201625
|
| Function |
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:16239426}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}; Single-pass type II membrane protein {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}. Note=Ligand binding leads to internalization.
|
| Tissue Specificity |
Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages. {ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15548716, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:16838277}.
|
