Gene Symbol | WEE2 |
---|---|
Entrez Gene | 494551 |
Alt Symbol | WEE1B |
Species | Human |
Gene Type | protein-coding |
Description | WEE1 homolog 2 (S. pombe) |
Other Description | wee1-like protein kinase 1B|wee1-like protein kinase 2|wee1B kinase |
Swissprots | P0C1S8 |
Accessions | EAW83977 P0C1S8 AK131218 BC172300 AAI72300 BG402079 BM790836 NM_001105558 NP_001099028 |
Function | Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11029659}. |
Tissue Specificity | Expressed in testis. {ECO:0000269|PubMed:11029659}. |
Top Pathways | Cell cycle |
Wee 2 (E-15) - sc-249349 from Santa Cruz Biotechnology
|
||||||||
Wee 2 (N-15) - sc-249348 from Santa Cruz Biotechnology
|
||||||||
Anti-WEE2 antibody - ab173363 from Abcam
|
||||||||
Anti-WEE2 antibody - ab121943 from Abcam
|
||||||||
Anti-WEE2 antibody - ab138162 from Abcam
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa364-393, FITC) - LS-C242735 from LifeSpan Bioscience
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa364-393, APC) - LS-C242733 from LifeSpan Bioscience
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa364-393, AP) - LS-C242731 from LifeSpan Bioscience
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa364-393, PE) - LS-C242736 from LifeSpan Bioscience
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa138-187) - LS-C200819 from LifeSpan Bioscience
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa364-393, Azide-free, HRP) - LS-C247251 from LifeSpan Bioscience
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa363-393) - LS-C326354 from LifeSpan Bioscience
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa151-200) - LS-C120469 from LifeSpan Bioscience
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa364-393) - LS-C164599 from LifeSpan Bioscience
|
||||||||
Anti-WEE1B / WEE2 Antibody (aa364-393, Biotin) - LS-C242734 from LifeSpan Bioscience
|
||||||||
WEE2 Antibody - NBP1-83676 from Novus Biologicals
|
||||||||
Anti-WEE2 antibody produced in rabbit - SAB4502038 from Sigma-Aldrich
|
||||||||
WEE2 Antibody (OAAF07289) - OAAF07289 from Aviva Systems Biology
|
||||||||
WEE2 Antibody (OAAF07941) - OAAF07941 from Aviva Systems Biology
|
||||||||
WEE2 Antibody (OAEC03195) - OAEC03195 from Aviva Systems Biology
|
||||||||
WEE2 antibody - 70R-21317 from Fitzgerald
|
||||||||
Mouse Wee2 Antibody - abx028077 from Abbexa
|
||||||||
WEE2 antibody - 55119-1-AP from Acris Antibodies
|
||||||||
Anti-Wee 2 antibody - STJ96269 from St John's Laboratory Ltd
|
||||||||
WEE2 antibody - 55119-1-AP from Proteintech Group
|