WEE2

Gene Symbol	WEE2
Entrez Gene	494551
Alt Symbol	WEE1B
Species	Human
Gene Type	protein-coding
Description	WEE1 homolog 2 (S. pombe)
Other Description	wee1-like protein kinase 1B|wee1-like protein kinase 2|wee1B kinase
Swissprots	P0C1S8
Accessions	EAW83977 P0C1S8 AK131218 BC172300 AAI72300 BG402079 BM790836 NM_001105558 NP_001099028
Function	Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11029659}.
Tissue Specificity	Expressed in testis. {ECO:0000269|PubMed:11029659}.
Top Pathways	Cell cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

WEE1B / WEE2 Antibody Blocking Peptide - LS-E3308 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Wee1-like protein kinase 2(WEE2) - CSB-YP026085HU CSB-EP026085HU CSB-BP026085HU CSB-MP026085HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WEE2 - TP325964 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Wee1-like protein kinase 2 (WEE2) , Recombinant Protein - MBS1158089 from MyBioSource Category Protein Prices $2,270.00, $2,270.00, $2,730.00, $2,730.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

WEE2 Recombinant Protein Antigen - NBP1-83676PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

WEE2 Peptide, Human - M34GP17475H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human WEE2 Protein, MYC/DDK-tagged - WEE2-365H from Creative Biomart Category Protein Source HEK293 Species Human

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