| Gene Symbol |
WEE2
|
| Entrez Gene |
494551
|
| Alt Symbol |
WEE1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WEE1 homolog 2 (S. pombe)
|
| Other Description |
wee1-like protein kinase 1B|wee1-like protein kinase 2|wee1B kinase
|
| Swissprots |
P0C1S8
|
| Accessions |
EAW83977 P0C1S8 AK131218 BC172300 AAI72300 BG402079 BM790836 NM_001105558 NP_001099028
|
| Function |
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11029659}.
|
| Tissue Specificity |
Expressed in testis. {ECO:0000269|PubMed:11029659}.
|
| Top Pathways |
Cell cycle
|