WEE2

Gene Symbol WEE2
Entrez Gene 494551
Alt Symbol WEE1B
Species Human
Gene Type protein-coding
Description WEE1 homolog 2 (S. pombe)
Other Description wee1-like protein kinase 1B|wee1-like protein kinase 2|wee1B kinase
Swissprots P0C1S8
Accessions EAW83977 P0C1S8 AK131218 BC172300 AAI72300 BG402079 BM790836 NM_001105558 NP_001099028
Function Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11029659}.
Tissue Specificity Expressed in testis. {ECO:0000269|PubMed:11029659}.
Top Pathways Cell cycle

Wee 2 CRISPR/Cas9 KO Plasmid (h) - sc-409420 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Wee 2 HDR Plasmid (h) - sc-409420-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Wee 2 Double Nickase Plasmid (h) - sc-409420-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Wee 2 Double Nickase Plasmid (h2) - sc-409420-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Wee 2 CRISPR Activation Plasmid (h) - sc-409420-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Wee 2 CRISPR Activation Plasmid (h2) - sc-409420-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Wee 2 Lentiviral Activation Particles (h) - sc-409420-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Wee 2 Lentiviral Activation Particles (h2) - sc-409420-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Wee 2 siRNA (h) - sc-106809 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Wee 2 shRNA Plasmid (h) - sc-106809-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Wee 2 shRNA (h) Lentiviral Particles - sc-106809-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU103211 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK2462 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2463 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2461 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN22876 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22876 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

WEE2 siRNA (Human) - CRJ8372 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

WEE2 - MBS8223985 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Wee2 (NM_001105558.1) - SHH446745 from Creative biogene

Category siRNA
Species Reactivities Human

WEE2 shRNA Plasmid (Human) - CHJ8372 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

WEE2 miRNA 3'UTR clone - MiUTR4H-TG09879 from Creative biogene

Species Reactivities Human
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