AEN

Gene Symbol AEN
Entrez Gene 64782
Alt Symbol ISG20L1, pp12744
Species Human
Gene Type protein-coding
Description apoptosis enhancing nuclease
Other Description apoptosis-enhancing nuclease|interferon stimulated exonuclease gene 20kDa-like 1|interferon-stimulated 20 kDa exonuclease-like 1
Swissprots C9J571 Q9H9X7 Q8WTP8 Q9BSA5
Accessions CCQ43693 EAX02009 EAX02010 EAX02011 Q8WTP8 AB209323 BAD92560 AF318330 AAL55837 AF327352 AAL56012 AK022546 BAB14091 AK022624 AK308119 BC005164 AAH05164 BC014407 AAH14407 BC020988 AAH20988 CA441442 HQ447809 ADQ32293 XM_005254966 XP_005255023 XM_005254967 XP_005255024 XM_006720645 XP_006720708 XM_011521905 XP_011520207 NM_022767 NP_073604
Function Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. {ECO:0000269|PubMed:16171785, ECO:0000269|PubMed:18264133}.
Subcellular Location Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.

AEN-Over-expression-Lysate - LY10313a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag AEN (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the AEN gene (Lane 2, Cat. #LY10313a).

ISG20L1 293T Cell Transient Overexpression Lysate(Denatured) - H00064782-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

AEN overexpression lysate - LY402942 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

AEN 293 Cell Lysate - 402563 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Apoptosis enhancing nuclease Overexpression Lysate (Denatured) - H00064782-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: ISG20L1 transfected lysate (35.86 KDa) Lane 2: Non-transfected lysate.

Apoptosis enhancing nuclease Overexpression Lysate (Native) - NBL1-12048 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Apoptosis enhancing nuclease Overexpression Lysate (Adult Normal) [NBL1-12048] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Apoptosis enhancing nuclease.

AEN Over-expression Lysate Product - GWB-74EFE4 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human AEN Knockdown Stable Cell Line - CSC-DC000345 from Creative biogene

Category Cell Line
Species Human
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