AEN

Gene Symbol	AEN
Entrez Gene	64782
Alt Symbol	ISG20L1, pp12744
Species	Human
Gene Type	protein-coding
Description	apoptosis enhancing nuclease
Other Description	apoptosis-enhancing nuclease|interferon stimulated exonuclease gene 20kDa-like 1|interferon-stimulated 20 kDa exonuclease-like 1
Swissprots	C9J571 Q9H9X7 Q8WTP8 Q9BSA5
Accessions	CCQ43693 EAX02009 EAX02010 EAX02011 Q8WTP8 AB209323 BAD92560 AF318330 AAL55837 AF327352 AAL56012 AK022546 BAB14091 AK022624 AK308119 BC005164 AAH05164 BC014407 AAH14407 BC020988 AAH20988 CA441442 HQ447809 ADQ32293 XM_005254966 XP_005255023 XM_005254967 XP_005255024 XM_006720645 XP_006720708 XM_011521905 XP_011520207 NM_022767 NP_073604
Function	Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. {ECO:0000269|PubMed:16171785, ECO:0000269|PubMed:18264133}.
Subcellular Location	Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AEN protein - orb246594 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

AEN fusion protein - ag2979 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human AEN - AEN-972H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant human Apoptosis-enhancing nuclease - CSB-EP819883HU CSB-BP819883HU CSB-MP819883HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Apoptosis-enhancing nuclease - CSB-EP819883HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Apoptosis-enhancing nuclease(AEN) - CSB-YP819883HU CSB-BP819883HU CSB-MP819883HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

AEN / ISG20L1 - TP302285 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Apoptosis-enhancing nuclease(AEN) , Recombinant Protein - MBS1340813 from MyBioSource Category Protein Prices $1,705.00, $1,705.00, $2,170.00, $2,170.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Apoptosis-enhancing nuclease(AEN) , Recombinant Protein - MBS1443759 from MyBioSource Category Protein Prices $1,705.00, $1,705.00, $2,170.00, $2,170.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

Apoptosis enhancing nuclease Protein - NBP2-14272PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

AEN-Antibody-N-term-Blocking-peptide - BP10115a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AEN Peptide, Human - M34GP00345H from Creative Peptides Category Peptide Source Synthetic. Species Human

AEN Recombinant Protein (OPCA02355) - OPCA02355 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Apoptosis-enhancing nuclease - AP71400 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Recombinant Human AEN Protein (117-325 aa), His-SUMO-tagged - AEN-1066H from Creative Biomart Category Protein Source E. coli Species Human

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