| Gene Symbol |
AEN
|
| Entrez Gene |
64782
|
| Alt Symbol |
ISG20L1, pp12744
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apoptosis enhancing nuclease
|
| Other Description |
apoptosis-enhancing nuclease|interferon stimulated exonuclease gene 20kDa-like 1|interferon-stimulated 20 kDa exonuclease-like 1
|
| Swissprots |
C9J571 Q9H9X7 Q8WTP8 Q9BSA5
|
| Accessions |
CCQ43693 EAX02009 EAX02010 EAX02011 Q8WTP8 AB209323 BAD92560 AF318330 AAL55837 AF327352 AAL56012 AK022546 BAB14091 AK022624 AK308119 BC005164 AAH05164 BC014407 AAH14407 BC020988 AAH20988 CA441442 HQ447809 ADQ32293 XM_005254966 XP_005255023 XM_005254967 XP_005255024 XM_006720645 XP_006720708 XM_011521905 XP_011520207 NM_022767 NP_073604
|
| Function |
Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. {ECO:0000269|PubMed:16171785, ECO:0000269|PubMed:18264133}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.
|