| Gene Symbol |
CLEC4E
|
| Entrez Gene |
26253
|
| Alt Symbol |
CLECSF9, MINCLE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C-type lectin domain family 4, member E
|
| Other Description |
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9|C-type lectin domain family 4 member E|C-type lectin superfamily member 9|macrophage-inducible C-type lectin
|
| Swissprots |
B2R6Q6 Q9ULY5
|
| Accessions |
EAW88617 EAW88618 Q9ULY5 AB024718 BAA83755 AK312671 BAG35553 AY358499 AAQ88863 BC000715 AAH00715 DA669951 DA678013 HQ448733 ADQ33211 XM_011520614 XP_011518916 XM_011520615 XP_011518917 NM_014358 NP_055173
|
| Function |
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. {ECO:0000269|PubMed:18509109}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Top Pathways |
Tuberculosis
|
![Western Blot: CLEC4E Overexpression Lysate (Adult Normal) [NBL1-09261] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CLEC4E.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/965_CLEC4E%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09261-img0002.jpg)