CLEC4E

Gene Symbol CLEC4E
Entrez Gene 26253
Alt Symbol CLECSF9, MINCLE
Species Human
Gene Type protein-coding
Description C-type lectin domain family 4, member E
Other Description C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9|C-type lectin domain family 4 member E|C-type lectin superfamily member 9|macrophage-inducible C-type lectin
Swissprots B2R6Q6 Q9ULY5
Accessions EAW88617 EAW88618 Q9ULY5 AB024718 BAA83755 AK312671 BAG35553 AY358499 AAQ88863 BC000715 AAH00715 DA669951 DA678013 HQ448733 ADQ33211 XM_011520614 XP_011518916 XM_011520615 XP_011518917 NM_014358 NP_055173
Function C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. {ECO:0000269|PubMed:18509109}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Top Pathways Tuberculosis

CLEC-4E CRISPR/Cas9 KO Plasmid (h) - sc-408056 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-4E HDR Plasmid (h) - sc-408056-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-4E Double Nickase Plasmid (h) - sc-408056-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-4E Double Nickase Plasmid (h2) - sc-408056-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-4E CRISPR Activation Plasmid (h) - sc-408056-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-4E CRISPR Activation Plasmid (h2) - sc-408056-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-4E Lentiviral Activation Particles (h) - sc-408056-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-4E Lentiviral Activation Particles (h2) - sc-408056-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLEC-4E siRNA (h) - sc-95678 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLEC-4E shRNA Plasmid (h) - sc-95678-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLEC-4E shRNA (h) Lentiviral Particles - sc-95678-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLEC4E RNAi - H00026253-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU035101 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6217 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6217 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CLEC4E siRNA (Human) - CRH8779 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLEC4E - MBS8214634 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CLEC4E (NM_014358.2) - SHH265169 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CLEC4E(NM_014358.2) - SHG181999 from Creative biogene

Category siRNA
Species Reactivities Human

CLEC4E shRNA Plasmid (Human) - CHH8779 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CLEC4E miRNA 3'UTR clone - MiUTR1H-02212 from Creative biogene

Species Reactivities Human
Search more