CLEC4E

Gene Symbol CLEC4E
Entrez Gene 26253
Alt Symbol CLECSF9, MINCLE
Species Human
Gene Type protein-coding
Description C-type lectin domain family 4, member E
Other Description C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9|C-type lectin domain family 4 member E|C-type lectin superfamily member 9|macrophage-inducible C-type lectin
Swissprots B2R6Q6 Q9ULY5
Accessions EAW88617 EAW88618 Q9ULY5 AB024718 BAA83755 AK312671 BAG35553 AY358499 AAQ88863 BC000715 AAH00715 DA669951 DA678013 HQ448733 ADQ33211 XM_011520614 XP_011518916 XM_011520615 XP_011518917 NM_014358 NP_055173
Function C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. {ECO:0000269|PubMed:18509109}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Top Pathways Tuberculosis

CLEC-4E (B-7) - sc-390806 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLEC-4E (B-7): sc-390806. Western blot analysis of CLEC-4E expression in non-transfected (A) and human CLEC-4E transfected (B) CMV whole cell lysates.

CLEC-4E (E-5) - sc-390807 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLEC-4E (E-5): sc-390807. Western blot analysis of CLEC-4E expression in non-transfected (A) and human CLEC-4E transfected (B) CMV whole cell lysates.

CLEC-4E (H-46) - sc-367006 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CLEC-4E (T-14) - sc-161488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CLEC4E antibody - ab66128 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-CLEC4E antibody [2A8] - ab131570 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A8
All lanes : Anti-CLEC4E antibody [2A8] (ab131570) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY CLEC4E cDNALysates/proteins at 5 µg per lane.

Anti-CLEC4E antibody [AT16E3] - ab100846 from Abcam

Prices $385.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT16E3
Anti-CLEC4E antibody [AT16E3] (ab100846) at 1/1000 dilution + HeLa Cell Lysate at 35 µgSecondarygoat anti-mouse conjugated to HRP developed using the ECL technique

Anti-CLEC4E / MINCLE Antibody (clone 2H4) - LS-C337815 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H4
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-CLEC4E mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-CLEC4E / MINCLE Antibody - LS-C113050 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CLEC4E / MINCLE Antibody (aa41-219) - LS-C128191 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal

Anti-CLEC4E / MINCLE Antibody - LS-C306987 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CLEC4E / MINCLE Antibody (clone 3F4) - LS-C337827 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CLEC4E (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CLEC4E.

Anti-CLEC4E / MINCLE Antibody (clone 2A8) - LS-C174145 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A8
IHC of paraffin-embedded Human lymphoma tissue using anti-CLEC4E mouse monoclonal antibody.

CLEC4E Antibody (16E3) - NBP1-49311 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 16E3
Western Blot: CLEC4E Antibody (16E3) [NBP1-49311] - The Cell lysates (40ug) were resolved by SDS-PAGE,transferred to PVDF membrane and probed with anti-human MINCLE antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1. : 293T cell lysate Lane 2. : CLEC4E transfected 293T cell lysate

CLEC4E Antibody - NBP2-27093 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CLEC4E Antibody [NBP2-27093] - analysis of CLEC4E using CLEC4E antibody. Human spleen cell lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse spleen, 4) rat spleen, 5) Ramos and 6) THP1 cell lysate probed with 2 ug/ml of CLEC4E antibody. ¡¦s goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

CLEC4E Antibody - NBP2-13844 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CLEC4E Antibody [NBP2-13844] - Analysis in human spleen tissue.

CLEC4E Antibody (2D12) - H00026253-M08 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D12
Western Blot: CLEC4E Antibody (2D12) [H00026253-M08] - Analysis of CLEC4E expression in K-562.

CLEC4E Antibody (2F2) - H00026253-M01A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2F2

CLEC4E Antibody - H00026253-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

CLEC4E Antibody (16E3) [DyLight 350] - NBP1-49311UV from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 16E3

CLEC4E Antibody (16E3) [DyLight 405] - NBP1-49311V from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 16E3

CLEC4E Antibody (16E3) [7C] - NBP1-49311V2 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 16E3

CLEC4E Antibody (16E3) [Alexa Fluor (R) 700] - NBP1-49311AF700 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 16E3

CLEC4E Antibody (16E3) [Alexa Fluor (R) 647] - NBP1-49311AF647 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 16E3

CLEC4E Antibody (16E3) [Alexa Fluor (R) 488] - NBP1-49311AF488 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 16E3
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