CLEC4E

Gene Symbol	CLEC4E
Entrez Gene	26253
Alt Symbol	CLECSF9, MINCLE
Species	Human
Gene Type	protein-coding
Description	C-type lectin domain family 4, member E
Other Description	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9|C-type lectin domain family 4 member E|C-type lectin superfamily member 9|macrophage-inducible C-type lectin
Swissprots	B2R6Q6 Q9ULY5
Accessions	EAW88617 EAW88618 Q9ULY5 AB024718 BAA83755 AK312671 BAG35553 AY358499 AAQ88863 BC000715 AAH00715 DA669951 DA678013 HQ448733 ADQ33211 XM_011520614 XP_011518916 XM_011520615 XP_011518917 NM_014358 NP_055173
Function	C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. {ECO:0000269|PubMed:18509109}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Top Pathways	Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLEC4E full length protein - ab153273 from Abcam Category Protein Source Wheat germ Species Human

Human CLEC4E protein fragment - ab152015 from Abcam Category Protein Source HEK 293 cells Species Human

CLEC4E Recombinant Protein - H00026253-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Human CLEC4E protein - orb49315 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

CLEC4E protein (His tag) - 80R-4159 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

CLEC4E (41-219, His-tag) - AR51845PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CLEC4E (41-219, His-tag) - AR51845PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CLEC4E - H00026253-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CLEC4E - H00026253-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

C-Type Lectin Domain Family 4 Member E, CLEC4E, Human, Recombinant - 19-C588 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source HEK293 Species Human

CLEC4E fusion protein - ag7288 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CLEC4E fusion protein - ag7292 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CLEC4E Protein - BP001767-C588 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human CLEC4E, His-tagged - CLEC4E-7776H from Creative Biomart Category Protein Source HEK293 Cells Species Human

Recombinant Human C-type lectin domain family 4 member E(CLEC4E) - CSB-YP891553HU CSB-EP891553HU CSB-BP891553HU CSB-MP891553HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CLEC4E, 41-219aa, Human, His tag, E.coli (Denatured) - ATGP3025 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CLEC4E - TP300244 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CLEC4E - TP720695 from Acris Antibodies Category Protein Prices $139.00 Sizes 10 µg Source HEK293 cells Species Human

C-type lectin domain family 4 member E (CLEC4E), Recombinant Protein - MBS1426666 from MyBioSource Category Protein Prices $925.00, $925.00, $1,145.00, $1,145.00, $1,375.00, $1,375.00, $1,830.00, $1,830.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human CLEC4E protein, His-tagged - CLEC4E-15H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human CLEC4E Fc Chimera Protein, CF - 8995-CL from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived MD Human IgG 1 (Pro100-Lys330) IEGR Human CLEC4E (Arg41-Leu219) Accession # Q9ULY5 N-terminus C-terminus Species Human

CLEC4E Recombinant Protein Antigen - NBP2-13844PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CLEC4E Peptide, Human - M34GP03270H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human CLEC4E Protein - NBP2-52028 from Novus Biologicals Category Protein Prices $259.00, $759.00 Sizes 100 µg, 500 µg Source E. coli Species Human

CLEC4E - PAT-83006-2 from Nordic BioSite Category Protein Species Human

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