| Gene Symbol | CLEC4E |
|---|---|
| Entrez Gene | 26253 |
| Alt Symbol | CLECSF9, MINCLE |
| Species | Human |
| Gene Type | protein-coding |
| Description | C-type lectin domain family 4, member E |
| Other Description | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9|C-type lectin domain family 4 member E|C-type lectin superfamily member 9|macrophage-inducible C-type lectin |
| Swissprots | B2R6Q6 Q9ULY5 |
| Accessions | EAW88617 EAW88618 Q9ULY5 AB024718 BAA83755 AK312671 BAG35553 AY358499 AAQ88863 BC000715 AAH00715 DA669951 DA678013 HQ448733 ADQ33211 XM_011520614 XP_011518916 XM_011520615 XP_011518917 NM_014358 NP_055173 |
| Function | C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. {ECO:0000269|PubMed:18509109}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Top Pathways | Tuberculosis |