| Gene Symbol |
SETDB2
|
| Entrez Gene |
83852
|
| Alt Symbol |
C13orf4, CLLD8, CLLL8, KMT1F
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET domain, bifurcated 2
|
| Other Description |
chronic lymphocytic leukemia deletion region 8|chronic lymphocytic leukemia deletion region gene 8 protein|histone-lysine N-methyltransferase SETDB2|lysine N-methyltransferase 1F
|
| Swissprots |
Q96AI6 Q86UD6 Q5TC65 Q659A7 Q5W0A7 Q5TC66 Q96T68
|
| Accessions |
EAX08824 EAX08825 EAX08826 Q96T68 AB209349 BAD92586 AF086317 AF277186 AF334407 AAK38373 AK307593 AK308220 AK308354 AK311602 AL831937 CAH56265 AL833957 CAD38807 AW297242 BC017078 AAH17078 BC028202 BC047434 AAH47434 DB164537 XM_005266568 XP_005266625 XM_005266569 XP_005266626 XM_005266572 XP_005266629 XM_011535269 XP_011533571 XM_011535270 XP_011533572 XM_011535271 XP_011533573 XM_011535272 XP_011533574 XM_011535273 XP_011533575 XM_011535274 XP_011533576 XM_011535275 XP_011533577 XM_011535276 XP_011533578 XM_011535277 XP_011533579 XR_941678 XR_941680 NM_001160308 NP_001153780 NM_031915 NP_114121
|
| Function |
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269|PubMed:20404330}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20404330}. Chromosome {ECO:0000305|PubMed:20404330}.
|
| Tissue Specificity |
Ubiquitous. Highest expression in heart, testis and ovary.
|
| Top Pathways |
Lysine degradation
|