SETDB2

Gene Symbol	SETDB2
Entrez Gene	83852
Alt Symbol	C13orf4, CLLD8, CLLL8, KMT1F
Species	Human
Gene Type	protein-coding
Description	SET domain, bifurcated 2
Other Description	chronic lymphocytic leukemia deletion region 8|chronic lymphocytic leukemia deletion region gene 8 protein|histone-lysine N-methyltransferase SETDB2|lysine N-methyltransferase 1F
Swissprots	Q96AI6 Q86UD6 Q5TC65 Q659A7 Q5W0A7 Q5TC66 Q96T68
Accessions	EAX08824 EAX08825 EAX08826 Q96T68 AB209349 BAD92586 AF086317 AF277186 AF334407 AAK38373 AK307593 AK308220 AK308354 AK311602 AL831937 CAH56265 AL833957 CAD38807 AW297242 BC017078 AAH17078 BC028202 BC047434 AAH47434 DB164537 XM_005266568 XP_005266625 XM_005266569 XP_005266626 XM_005266572 XP_005266629 XM_011535269 XP_011533571 XM_011535270 XP_011533572 XM_011535271 XP_011533573 XM_011535272 XP_011533574 XM_011535273 XP_011533575 XM_011535274 XP_011533576 XM_011535275 XP_011533577 XM_011535276 XP_011533578 XM_011535277 XP_011533579 XR_941678 XR_941680 NM_001160308 NP_001153780 NM_031915 NP_114121
Function	Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269|PubMed:20404330}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:20404330}. Chromosome {ECO:0000305|PubMed:20404330}.
Tissue Specificity	Ubiquitous. Highest expression in heart, testis and ovary.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLLD8/SETDB2 full length protein - ab169554 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human CLLD8/SETDB2 peptide - ab24398 from Abcam Category Peptide

Human CLLD8/SETDB2 peptide - ab23232 from Abcam Category Peptide Species Human

Human CLLD8/SETDB2 protein fragment - ab153544 from Abcam Category Protein Source Wheat germ Species Human

Human CLLD8/SETDB2 protein fragment - ab153545 from Abcam Category Protein Source Wheat germ Species Human

SETDB2 Antibody Blocking Peptide - LS-E27649 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SETDB2 Antibody Blocking Peptide - LS-E25457 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SETDB2 Antibody Blocking Peptide - LS-E17710 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SETDB2 Protein - H00083852-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SETDB2 Protein - H00083852-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SETDB2 blocking peptide - GTX13712-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Bovine

SETDB2 Blocking Peptide - 33R-1523 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CLLD8/SETDB2 Peptide - AC21-0286-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CLLD8/SETDB2 Peptide - AC21-2467-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SETDB2 / CLLD8 - H00083852-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SETDB2 / CLLD8 - H00083852-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SETDB2 / CLLD8 - H00083852-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

SETDB2 / CLLD8 - H00083852-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SETDB2 / CLLD8 - H00083852-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SETDB2 Peptide - 46-361P from ProSci Category Peptide Species Human

SETDB2 Peptide - 42-978P from ProSci Category Peptide Species Human

SETDB2 fusion protein - ag5112 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SETDB2 fusion protein - Ag5795 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SET Domain, Bifurcated 2, GST-tagged - SETDB2-1632H from Creative Biomart Category Protein Species Human

Recombinant Human SETDB2, GST-tagged - SETDB2-6965H from Creative Biomart Category Protein Source Sf9 Cells Species Human

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