SETDB2

Gene Symbol SETDB2
Entrez Gene 83852
Alt Symbol C13orf4, CLLD8, CLLL8, KMT1F
Species Human
Gene Type protein-coding
Description SET domain, bifurcated 2
Other Description chronic lymphocytic leukemia deletion region 8|chronic lymphocytic leukemia deletion region gene 8 protein|histone-lysine N-methyltransferase SETDB2|lysine N-methyltransferase 1F
Swissprots Q96AI6 Q86UD6 Q5TC65 Q659A7 Q5W0A7 Q5TC66 Q96T68
Accessions EAX08824 EAX08825 EAX08826 Q96T68 AB209349 BAD92586 AF086317 AF277186 AF334407 AAK38373 AK307593 AK308220 AK308354 AK311602 AL831937 CAH56265 AL833957 CAD38807 AW297242 BC017078 AAH17078 BC028202 BC047434 AAH47434 DB164537 XM_005266568 XP_005266625 XM_005266569 XP_005266626 XM_005266572 XP_005266629 XM_011535269 XP_011533571 XM_011535270 XP_011533572 XM_011535271 XP_011533573 XM_011535272 XP_011533574 XM_011535273 XP_011533575 XM_011535274 XP_011533576 XM_011535275 XP_011533577 XM_011535276 XP_011533578 XM_011535277 XP_011533579 XR_941678 XR_941680 NM_001160308 NP_001153780 NM_031915 NP_114121
Function Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269|PubMed:20404330}.
Subcellular Location Nucleus {ECO:0000269|PubMed:20404330}. Chromosome {ECO:0000305|PubMed:20404330}.
Tissue Specificity Ubiquitous. Highest expression in heart, testis and ovary.
Top Pathways Lysine degradation

H3-K9-HMTase (Y-19) - sc-54503 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
H3-K9-HMTase (Y-19): sc-54503. Western blot analysis of H3-K9-HMTase expression in Hep G2 nuclear extract.

H3-K9-HMTase (LD87) - sc-130475 from Santa Cruz Biotechnology

Prices $295.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
H3-K9-HMTase (LD87): sc-130475. Western blot analysis of H3-K9-HMTase expression in MES-SA/Dx5 whole cell lysate.

H3-K9-HMTase (K-19) - sc-54457 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CLLD8/SETDB2 antibody - ab5517 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CLLD8/SETDB2 antibody (ab5517) at 1 µg/ml + Human CLLD8/SETDB2 full length protein (ab169554) at 0.01 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.Additional bands at : 120 kDa (possible tagged protein).Exposure time : 10 secondsab5517 recognises a band corresponding to the tagged CLLD8/SETB2 at approximately 120 kDa. Abcam recommends using milk as the blocking agent. Abcam welcomes customer feedback and would appreciate any comments regarding this product and the data presented above.

Anti-CLLD8/SETDB2 antibody - ab56184 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab56184 staining CLLD8/SETDB2 in 293T cells by Immunocytochemistry/ Immunofluorescence.After 2–6 days, the cells grown on coverslips were washed and fixed with 4% paraformaldehyde for 10 minutes, permeabilized, and incubated with ab56184 at a 1/50 dilution for 1 hour at 37 °C. A secondary antibody directed against the rabbit primary antibody conjugated with Alexa-Fluor 488 was used for detection. The nuclei were counterstained with DAPI.

Anti-CLLD8/SETDB2 antibody - ab89173 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-CLLD8/SETDB2 antibody (ab89173) at 5 µg/ml + tagged, recombinant human CLLD8/SETDB2 protein fragment (the immunogen) at 0.2 µgdeveloped using the ECL technique

Anti-CLLD8/SETDB2 antibody - N-terminal - ab155243 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CLLD8/SETDB2 antibody - N-terminal (ab155243) at 1/1000 dilution + SK-N-SH whole cell lysate at 30 µg

Anti-SETDB2 Antibody (N-Terminus) - LS-C47123 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SETDB2 Antibody (aa620-720, clone 10B2475, Azide-free) - LS-C183715 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10B2475

Anti-SETDB2 Antibody (clone 2F4) - LS-C139445 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4
SETDB2 monoclonal antibody (M17), clone 2F4. Western blot of SETDB2 expression in A-431.

Anti-SETDB2 Antibody (aa71-120) - LS-C111208 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SETDB2 antibody LS-C111208 Western blot of Placenta lysate.

Anti-SETDB2 Antibody (aa2-14) - LS-C54492 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.5 ug/ml) staining of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SETDB2 Antibody (aa174-188) - LS-C154843 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
SETDB2 antibody (0.1 ug/ml) staining of Human Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SETDB2 Antibody - NBP1-31264 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SETDB2 Antibody [NBP1-31264] - Analysis on: A: HepG2 7.5% SDS PAGE diluted at 1:1000

SETDB2 Antibody - NB100-1137 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: SETDB2 Antibody [NB100-1137] - Analysis of SETDB2 of Human Heart lysate (35ug protein in RIPA buffer) using this antibody at 0.5 ug/ml.

SETDB2 Antibody - NBP2-20323 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SETDB2 Antibody (1E2) - H00083852-M07A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 1E2
Western Blot: SETDB2 Antibody (1E2) [H00083852-M07A] - SETDB2 monoclonal antibody (M07), clone 1E2. Western Blot analysis of SETDB2 expression in MES-SA/Dx5 ( Cat # L021V1 ).

SETDB2 Antibody (1E2) - H00083852-M07 from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1E2
Western Blot: SETDB2 Antibody (1E2) [H00083852-M07] - Analysis of SETDB2 expression in MES-SA/Dx5 (Cat # L021V1).

SETDB2 Antibody (2F4) - H00083852-M17 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4
Western Blot: SETDB2 Antibody (2F4) [H00083852-M17] - Analysis of SETDB2 expression in A-431 (Cat # L015V1).

SETDB2 Antibody (2B11) - H00083852-M09A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2B11

SETDB2 Antibody (1H3) - H00083852-M22A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 1H3

CLLD8 Polyclonal Antibody - bs-6414R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SETDB2 (center V514) antibody produced in rabbit - SAB1300147 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SETDB2 (C or N-TERMINAL) antibody produced in goat - SAB2501995 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SETDB2 (C or N-terminal) <B>Cat. No. SAB2501995</B>: Immunoblotting (0.1 μg/mL) staining of Human Heart lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Monoclonal Anti-SETDB2 antibody produced in mouse - SAB1405299 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4
<B>Immunoblotting</B><BR/>Monoclonal Anti-SETDB2: <B>Cat. No. SAB1405299</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~81.9 kDa using A~431 lysate.
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