SETDB2

Gene Symbol SETDB2
Entrez Gene 83852
Alt Symbol C13orf4, CLLD8, CLLL8, KMT1F
Species Human
Gene Type protein-coding
Description SET domain, bifurcated 2
Other Description chronic lymphocytic leukemia deletion region 8|chronic lymphocytic leukemia deletion region gene 8 protein|histone-lysine N-methyltransferase SETDB2|lysine N-methyltransferase 1F
Swissprots Q96AI6 Q86UD6 Q5TC65 Q659A7 Q5W0A7 Q5TC66 Q96T68
Accessions EAX08824 EAX08825 EAX08826 Q96T68 AB209349 BAD92586 AF086317 AF277186 AF334407 AAK38373 AK307593 AK308220 AK308354 AK311602 AL831937 CAH56265 AL833957 CAD38807 AW297242 BC017078 AAH17078 BC028202 BC047434 AAH47434 DB164537 XM_005266568 XP_005266625 XM_005266569 XP_005266626 XM_005266572 XP_005266629 XM_011535269 XP_011533571 XM_011535270 XP_011533572 XM_011535271 XP_011533573 XM_011535272 XP_011533574 XM_011535273 XP_011533575 XM_011535274 XP_011533576 XM_011535275 XP_011533577 XM_011535276 XP_011533578 XM_011535277 XP_011533579 XR_941678 XR_941680 NM_001160308 NP_001153780 NM_031915 NP_114121
Function Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269|PubMed:20404330}.
Subcellular Location Nucleus {ECO:0000269|PubMed:20404330}. Chromosome {ECO:0000305|PubMed:20404330}.
Tissue Specificity Ubiquitous. Highest expression in heart, testis and ovary.
Top Pathways Lysine degradation

H3-K9-HMTase CRISPR/Cas9 KO Plasmid (h) - sc-413510 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

H3-K9-HMTase HDR Plasmid (h) - sc-413510-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

H3-K9-HMTase Double Nickase Plasmid (h) - sc-413510-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

H3-K9-HMTase Double Nickase Plasmid (h2) - sc-413510-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

H3-K9-HMTase CRISPR Activation Plasmid (h) - sc-413510-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

H3-K9-HMTase CRISPR Activation Plasmid (h2) - sc-413510-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

H3-K9-HMTase Lentiviral Activation Particles (h) - sc-413510-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

H3-K9-HMTase Lentiviral Activation Particles (h2) - sc-413510-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

H3-K9-HMTase siRNA (h) - sc-62429 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

H3-K9-HMTase shRNA Plasmid (h) - sc-62429-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

H3-K9-HMTase shRNA (h) Lentiviral Particles - sc-62429-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SETDB2 RNAi - H00083852-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU140971 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19175 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

SETDB2 siRNA (Human) - CRJ3202 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SETDB2 - MBS8206261 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SETDB2 (NM_031915.2) - SHH405684 from Creative biogene

Category siRNA
Species Reactivities Human

Human SETDB2 siRNA - orb273703 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SETDB2 shRNA Plasmid (Human) - CHJ3202 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SETDB2 miRNA 3'UTR clone - MiUTR4H-TG07974 from Creative biogene

Species Reactivities Human
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