| Gene Symbol |
MED1
|
| Entrez Gene |
5469
|
| Alt Symbol |
CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 1
|
| Other Description |
ARC205|PPAR binding protein|PPAR-binding protein|PPARG binding protein|TR-interacting protein 2|TRIP-2|activator-recruited cofactor 205 kDa component|mediator of RNA polymerase II transcription subunit 1|p53 regulatory protein RB18A|peroxisome proliferator-activated receptor-binding protein|thyroid hormone receptor-associated protein complex 220 kDa component|thyroid hormone receptor-associated protein complex component TRAP220|thyroid receptor interacting protein 2|thyroid receptor-interacting protein 2|vitamin D receptor-interacting protein 230 kD|vitamin D receptor-interacting protein complex component DRIP205
|
| Swissprots |
O75447 O43810 A2RRQ6 Q9HD39 Q6PK58 Q6P9H7 Q15648
|
| Accessions |
EAW60575 Q15648 AF055994 AAC39854 AF283812 AAF98352 AK299789 BAG61669 AK314185 BAG36866 BC006517 AAH06517 BC060758 AAH60758 BC131783 AAI31784 BP357374 JF432429 ADZ15646 L40366 AAC41736 Y13467 CAA73867 XM_005257465 XP_005257522 XM_006721957 XP_006722020 NM_004774 NP_004765
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:9653119}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:16314496, ECO:0000269|PubMed:16574658}. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:9444950, ECO:0000269|PubMed:9653119}.
|