MED1

Gene Symbol	MED1
Entrez Gene	5469
Alt Symbol	CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
Species	Human
Gene Type	protein-coding
Description	mediator complex subunit 1
Other Description	ARC205|PPAR binding protein|PPAR-binding protein|PPARG binding protein|TR-interacting protein 2|TRIP-2|activator-recruited cofactor 205 kDa component|mediator of RNA polymerase II transcription subunit 1|p53 regulatory protein RB18A|peroxisome proliferator-activated receptor-binding protein|thyroid hormone receptor-associated protein complex 220 kDa component|thyroid hormone receptor-associated protein complex component TRAP220|thyroid receptor interacting protein 2|thyroid receptor-interacting protein 2|vitamin D receptor-interacting protein 230 kD|vitamin D receptor-interacting protein complex component DRIP205
Swissprots	O75447 O43810 A2RRQ6 Q9HD39 Q6PK58 Q6P9H7 Q15648
Accessions	EAW60575 Q15648 AF055994 AAC39854 AF283812 AAF98352 AK299789 BAG61669 AK314185 BAG36866 BC006517 AAH06517 BC060758 AAH60758 BC131783 AAI31784 BP357374 JF432429 ADZ15646 L40366 AAC41736 Y13467 CAA73867 XM_005257465 XP_005257522 XM_006721957 XP_006722020 NM_004774 NP_004765
Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:9653119}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:16314496, ECO:0000269|PubMed:16574658}. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:9444950, ECO:0000269|PubMed:9653119}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRAP220/MED1 peptide - ab92663 from Abcam Category Peptide

Human TRAP220/MED1 protein fragment - ab159163 from Abcam Category Protein Source Wheat germ Species Human

TRAP220 Blocking Peptide - abx063111 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

MED1 - H00005469-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MED1 - H00005469-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MED1 fusion protein - Ag5222 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MED1 fusion protein - ag5241 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human MED1, GST-tagged - MED1-800H from Creative Biomart Category Protein Source E.coli Species Human

TRAP220 Blocking Peptide - CBP1917 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

TRAP220 (S1451) Peptide - BS1690P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

TRAP220 (P697) Peptide - BS2071P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Pongo abelii Mediator of RNA polymerase II transcription subunit 1( - CSB-YP732805PYX CSB-EP732805PYX CSB-BP732805PYX CSB-MP732805PYX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Orangutan

Recombinant Human Mediator of RNA polymerase II transcription subunit 1(MED1) ,partial - CSB-YP621880HU CSB-EP621880HU CSB-BP621880HU CSB-MP621880HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CRSP-1 - 3555 from R&D Systems Category Peptide Prices $219.00 Sizes 100 µg

TRAP220/MED1 Partial Recombinant Protein - H00005469-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRAP220 (pT1457) Blocking Peptide - abx161671 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

Recombinant Mediator Complex Subunit 1 (MED1) - RPC238Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mediator Complex Subunit 1 (MED1) - RPC238Hu01 from Cloud-clone Category Protein Source E.coli Species Human

TRAP220 (pT1457) Blocking Peptide - CBP4460 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

Recombinant Mediator Complex Subunit 1 (MED1) - RPU53093 from Biomatik Category Protein Prices $194.00, $396.00, $605.00, $721.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

MED1 Recombinant Protein (OPCD00546) - OPCD00546 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant Human Mediator of RNA polymerase II transcription subunit 1(MED1),partial - AP74605 from Signalway Antibody Category Protein Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

MED1 (Phospho-T1457) Blocking Peptide - orb392805 from Biorbyt Category Peptide Prices $340.00, $587.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

TRAP220/MED1 Recombinant Protein Antigen - NBP2-57045PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Mediator Complex Subunit 1, Recombinant Protein - MBS2033638 from MyBioSource Category Protein Prices $190.00, $395.00, $610.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

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