| Gene Symbol |
DCTN2
|
| Entrez Gene |
10540
|
| Alt Symbol |
DCTN50, DYNAMITIN, HEL-S-77, RBP50
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dynactin 2 (p50)
|
| Other Description |
50 kD dynein-associated polypeptide|50 kDa dynein-associated polypeptide|dynactin complex 50 kD subunit|dynactin complex 50 kDa subunit|dynactin subunit 2|epididymis secretory protein Li 77|p50 dynamitin
|
| Swissprots |
Q9BW17 Q86YN2 B2RBK5 Q13561
|
| Accessions |
EAW97027 EAW97028 EAW97029 Q13561 AK055682 BAG51555 AK096242 BAG53236 AK098794 AK222693 BAD96413 AK292364 BAF85053 AK314705 BAG37252 AY189155 AAO34395 BC000718 AAH00718 BC009468 AAH09468 BC014083 AAH14083 DB027733 DB569305 FJ224315 ACI46007 HQ447201 ADQ31688 U50733 AAC50423 XM_011537761 XP_011536063 XR_944481 NM_001261412 NP_001248341 NM_001261413 NP_001248342 NM_006400 NP_006391
|
| Function |
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:8647893}. Membrane {ECO:0000269|PubMed:8647893}; Peripheral membrane protein {ECO:0000269|PubMed:8647893}.
|
| Top Pathways |
Huntington's disease, Vasopressin-regulated water reabsorption
|
![Western Blot: DCTN-50 Overexpression Lysate (Adult Normal) [NBL1-09750] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DCTN-50.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9364_DCTN-50%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09750-img0002.jpg)