DOK2

Gene Symbol DOK2
Entrez Gene 9046
Alt Symbol p56DOK, p56dok-2
Species Human
Gene Type protein-coding
Description docking protein 2, 56kDa
Other Description docking protein 2|docking protein 2, 56kD|downstream of tyrosine kinase 2|p56(dok-2)
Swissprots O60496 Q8N5A4
Accessions EAW63738 EAW63739 O60496 AF034970 AAC13265 AK226110 AK292126 BAF84815 AK296671 BAG59268 AL545478 BC032623 AAH32623 BQ067133 CB270269 DQ890550 ABM92167 DQ896808 ABM87807 XM_005273680 XP_005273737 XM_005273681 XP_005273738 XM_006716411 XP_006716474 XM_011544690 XP_011542992 NM_003974 NP_003965 NM_201349
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}.
Tissue Specificity Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. {ECO:0000269|PubMed:9478921}.

Phospho-p56Dok-2 (Tyr351) Antibody - 3911 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells transfected with p56Dok-2 proteins, untreated or stimulated with anti-CD2 antibody, using Phospho-p56Dok-2 (Tyr351) Antibody (upper) or p56Dok-2 Antibody #3914 (lower).

p56Dok-2 Antibody - 3914 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat, 32D and BaF3 cells, transfected with p56Dok-2 and/or anti-CD2-treated as indicated, using p56Dok-2 Antibody.

Dok-2 (A-5) - sc-271781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dok-2 (A-5): sc-271781. Western blot analysis of Dok-2 expression in Jurkat whole cell lysate.

Dok-2 (C-19) - sc-8130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dok-2 (C-19): sc-8130. Western blot analysis of Dok-2 expression in Jurkat whole cell lysate.

Dok-2 (H-192) - sc-13952 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dok-2 (H-192): sc-13952. Western blot analysis of Dok-2 expression in Jurkat whole cell lysate.

Dok-2 (M-20) - sc-8131 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dok-2 (M-20): sc-8131. Western blot analysis of Dok-2 expression in CTLL-2 whole cell lysate.

Dok-2 (E-10) - sc-17830 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dok-2 (E-10): sc-17830. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing nuclear staining of paracortex cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Dok-2 (15) - sc-135889 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Dok-2 (15): sc-135889. Western blot analysis of Dok-2 expression in MEL whole cell lysate.

p-Dok-2 (Tyr 299) - sc-101765 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Dok-2 (Tyr 299): sc-101765. Western blot analysis of phosphorylated Dok-2 expression in K-562 (A) and starved K-562 (B) whole cell lysates.

Anti-DOK2 (phospho Y299) antibody - ab131461 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DOK2 (phospho Y299) antibody (ab131461) at 1/500 dilutionLane 1 : K562 cell extracts with blocking peptideLane 2 : K562 cell extracts

Anti-DOK2 (phospho Y299) antibody - ab194772 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DOK2 (phospho Y299) antibody (ab194772) at 1/500 dilutionLane 1 : Jurkat cell extract, untreatedLane 2 : Jurkat cell extract, treated with Insulin

Anti-DOK2 (phospho Y299) antibody - ab47376 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DOK2 (phospho Y299) antibody (ab47376) at 1/500 dilutionLane 1 : Untreated extracts from K562 cellsLane 2 : Extracts from K562 cells, treated with Starvation

Anti-DOK2 (phospho Y299) antibody - ab192429 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DOK2 (phospho Y299) antibody (ab192429) at 1/500 dilutionLane 1 : K562 whole cell lysates treated with the antigen-specific peptideLane 2 : K562 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-DOK2 antibody - ab47507 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab47507 at 1/50 dilution staining paraffin-embedded human breast carcinoma tissue; Left without and right with imunising peptide.

Anti-DOK2 antibody - ab131488 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of methanol-fixed HeLa cells labelling DOK2 with ab131488 at 1/100 dilution.

Anti-DOK2 antibody - ab1677 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab1677 staining human breast carcinoma. Staining is localized to nucleus and cytoplasm.Left panel: with primary antibody at 2 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffers EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-DOK2 antibody - ab37832 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DOK2 antibody (ab37832) at 1/100 dilution + CEM cell lysateSecondaryHRP-anti-rabbit

Anti-DOK2 Antibody (phospho-Tyr299) - LS-C335903 from LifeSpan Bioscience

Prices $285.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Phospho-DOK2-Tyr299 antibody.

Anti-DOK2 Antibody (phospho-Tyr351) - LS-C6436 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DOK2 Antibody (C-Terminus) - LS-C6435 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DOK2 Antibody (aa393-412) - LS-C22888 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DOK2 Antibody (phospho-Tyr299) - LS-C123410 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DOK2 Antibody - LS-C123411 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DOK2 Antibody (C-Terminus) - LS-C50493 from LifeSpan Bioscience

Prices $530.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human Breast Carcinoma stained with anti-DOK-2 antibody

Anti-DOK2 Antibody (C-Terminus, AP) - LS-C244211 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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