| Gene Symbol |
DOK2
|
| Entrez Gene |
9046
|
| Alt Symbol |
p56DOK, p56dok-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
docking protein 2, 56kDa
|
| Other Description |
docking protein 2|docking protein 2, 56kD|downstream of tyrosine kinase 2|p56(dok-2)
|
| Swissprots |
O60496 Q8N5A4
|
| Accessions |
EAW63738 EAW63739 O60496 AF034970 AAC13265 AK226110 AK292126 BAF84815 AK296671 BAG59268 AL545478 BC032623 AAH32623 BQ067133 CB270269 DQ890550 ABM92167 DQ896808 ABM87807 XM_005273680 XP_005273737 XM_005273681 XP_005273738 XM_006716411 XP_006716474 XM_011544690 XP_011542992 NM_003974 NP_003965 NM_201349
|
| Function |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. {ECO:0000269|PubMed:9478921}.
|