Gene Symbol | USP46 |
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Entrez Gene | 64854 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 46 |
Other Description | deubiquitinating enzyme 46|ubiquitin carboxyl-terminal hydrolase 46|ubiquitin thioesterase 46|ubiquitin thiolesterase 46|ubiquitin-specific-processing protease 46 |
Swissprots | G8ACC7 B7Z3Y7 B7Z7S3 B7Z675 P62068 |
Accessions | EAX05434 EAX05435 P62068 AF070557 AK021861 AK021912 AK022614 BAB14133 AK024318 BAB14881 AK024345 AK096712 AK296493 BAH12373 AK299883 BAH13161 AK302438 BAH13709 BC037574 AAH37574 BP371221 BU620990 CN483539 DQ896764 ABM87763 EU176797 ABW03598 GU455414 ADV57651 NM_001134223 NP_001127695 NM_001286767 NP_001273696 NM_001286768 NP_001273697 NM_022832 NP_073743 |
Function | Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. {ECO:0000269|PubMed:19075014}. |
Tissue Specificity | Broadly expressed. {ECO:0000269|PubMed:14715245}. |
USP46 CRISPR/Cas9 KO Plasmid (h) - sc-413045 from Santa Cruz Biotechnology
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USP46 HDR Plasmid (h) - sc-413045-HDR from Santa Cruz Biotechnology
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USP46 Double Nickase Plasmid (h) - sc-413045-NIC from Santa Cruz Biotechnology
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USP46 Double Nickase Plasmid (h2) - sc-413045-NIC-2 from Santa Cruz Biotechnology
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USP46 CRISPR Activation Plasmid (h) - sc-413045-ACT from Santa Cruz Biotechnology
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USP46 CRISPR Activation Plasmid (h2) - sc-413045-ACT-2 from Santa Cruz Biotechnology
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USP46 Lentiviral Activation Particles (h) - sc-413045-LAC from Santa Cruz Biotechnology
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USP46 Lentiviral Activation Particles (h2) - sc-413045-LAC-2 from Santa Cruz Biotechnology
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USP46 siRNA (h) - sc-76861 from Santa Cruz Biotechnology
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USP46 shRNA Plasmid (h) - sc-76861-SH from Santa Cruz Biotechnology
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USP46 shRNA (h) Lentiviral Particles - sc-76861-V from Santa Cruz Biotechnology
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USP46 RNAi - H00064854-R01 from Novus Biologicals
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MISSION® esiRNA - EHU005571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22595 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22595 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11621 from Sigma-Aldrich
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USP46 siRNA (Human) - CRJ2121 from Cohesion Biosciences
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USP46 - MBS8211655 from MyBioSource
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shRNA set against Human USP46 (NM_022832.3) - SHH441664 from Creative biogene
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Human USP46 siRNA - orb272622 from Biorbyt
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USP46 shRNA Plasmid (Human) - CHJ2121 from Cohesion Biosciences
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