| Gene Symbol |
XPA
|
| Entrez Gene |
7507
|
| Alt Symbol |
XP1, XPAC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
xeroderma pigmentosum, complementation group A
|
| Other Description |
DNA repair protein complementing XP-A cells|excision repair-controlling|mutant xeroderma pigmentosum complementation group A|xeroderma pigmentosum group A-complementing protein
|
| Swissprots |
P23025 Q6LCW7 Q6LD02 Q5T1U9
|
| Accessions |
AAA92883 AAB60404 AAM18969 EAW58855 P23025 AI961077 AL531629 BC014965 AAH14965 BT019518 AAV38325 CB155090 D14533 BAA03403 DQ893624 ABM84550 DQ895423 ABM86349 HG502281 KC899693 AHF45877 S89853 AAB21861 XM_006717278 XP_006717341 XM_011518988 XP_011517290 XR_929839 NM_000380 NP_000371 NR_027302
|
| Function |
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. {ECO:0000269|PubMed:19197159}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:20304803}.
|
| Tissue Specificity |
Expressed in various cell lines and in skin fibroblasts. {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:8543191}.
|
| Top Pathways |
Nucleotide excision repair
|
![Western Blot: XPA Overexpression Lysate (Adult Normal) [NBL1-17907] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for XPA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6976_XPA%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17907-img0002.jpg)