XPA

Gene Symbol XPA
Entrez Gene 7507
Alt Symbol XP1, XPAC
Species Human
Gene Type protein-coding
Description xeroderma pigmentosum, complementation group A
Other Description DNA repair protein complementing XP-A cells|excision repair-controlling|mutant xeroderma pigmentosum complementation group A|xeroderma pigmentosum group A-complementing protein
Swissprots P23025 Q6LCW7 Q6LD02 Q5T1U9
Accessions AAA92883 AAB60404 AAM18969 EAW58855 P23025 AI961077 AL531629 BC014965 AAH14965 BT019518 AAV38325 CB155090 D14533 BAA03403 DQ893624 ABM84550 DQ895423 ABM86349 HG502281 KC899693 AHF45877 S89853 AAB21861 XM_006717278 XP_006717341 XM_011518988 XP_011517290 XR_929839 NM_000380 NP_000371 NR_027302
Function Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. {ECO:0000269|PubMed:19197159}.
Subcellular Location Nucleus {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:20304803}.
Tissue Specificity Expressed in various cell lines and in skin fibroblasts. {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:8543191}.
Top Pathways Nucleotide excision repair

XPA (D9U5U) Rabbit mAb - 14607 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9U5U
Western blot analysis of extracts from 293T and Colo205 cells (high expression), and A549 and SNB19 cells (low expression), using XPA (D9U5U) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

XPA (B-1) - sc-28353 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XPA (B-1): sc-28353. Western blot analysis of XPA expression in mouse Lac Z whole cell lysate.

XPA (B-7) - sc-398005 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XPA (B-7): sc-398005. Western blot analysis of XPA expression in BJAB (A), MCF7 (B), TF-1 (C) and HeLa (D) nuclear extracts and HeLa whole cell lysate (E).

XPA (5A2) - sc-53468 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XPA (5A2): sc-53468. Western blot analysis of human recombinant XPA.

XPA (C-12) - sc-48711 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

XPA (FL-273) - sc-853 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
XPA siRNA (h): sc-36853. Western blot analysis of XPA expression in non-transfected control (A) and XPA siRNA transfected (B) HeLa cells. Blot probed with XPA (FL-273): sc-853. GAPDH (FL-335): sc-25778 used as specificity and loading control.

XPA (E-14) - sc-48713 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

XPA (N-16) - sc-48715 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XPA (N-16): sc-48715. Western blot analysis of XPA expression in GM637 (A) and mouse Lac Z (B) whole cell lysates.

XPA (SPM326) - sc-56497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XPA (SPM326): sc-56497. Western blot analysis of XPA expression in GM637 whole cell lysate.

XPA (C-14) - sc-48712 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

XPA (3F396) - sc-73273 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XPA (3F396): sc-73273. Western blot analysis of XPA expression in GM637 whole cell lysate.

XPA (2A4) - sc-53467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

XPA (3H55) - sc-73272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XPA (3H55): sc-73272. Western blot analysis of XPA expression in GM637 whole cell lysate.

XPA (12F5) - sc-56813 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XPA (12F5): sc-56813. Western blot analysis of XPA expression in MCF7 (A), BJAB (B) and TF-1 (C) nuclear extracts.

Anti-XPA antibody - ab85914 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling XPA with ab85914 at 1/1000 (0.2µg/ml). Detection: DAB.

Anti-XPA antibody - ab180618 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat brain tissue labelling XPA with ab180618 at 1/200. Magnification: 200x.

Anti-XPA antibody - ab84780 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84780, at a 1/500 dilution, staining XPA in formalin fixed, paraffin embedded human ovarian tumor by Immunohistochemistry using DAB staining.

Anti-XPA antibody - ab58464 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XPA antibody (ab58464) at 1/500 dilutionLane 1 : Extracts from COLO205 cellsLane 2 : Extracts from COLO205 cells with immunizing peptide

Anti-XPA antibody - ab93400 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-XPA antibody (ab93400) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-XPA antibody - ab10905 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-XPA antibody [12F5] - ab2352 from Abcam

Prices $384.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 12F5
Ab2352 (1:50) staining human XPA in human tonsil tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

Anti-XPA antibody [12F5] - ab44918 from Abcam

Prices $372.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 12F5

Anti-XPA antibody [2A4] - ab20252 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A4

Anti-XPA antibody [5A2] - ab44 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5A2

Anti-XPA antibody [5F12] - ab65963 from Abcam

Prices $382.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5F12
Anti-XPA antibody [5F12] (ab65963) at 0.1 µg/ml + Crude extract of HeLa cells at 200 µg
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