Gene Symbol | XPA |
---|---|
Entrez Gene | 7507 |
Alt Symbol | XP1, XPAC |
Species | Human |
Gene Type | protein-coding |
Description | xeroderma pigmentosum, complementation group A |
Other Description | DNA repair protein complementing XP-A cells|excision repair-controlling|mutant xeroderma pigmentosum complementation group A|xeroderma pigmentosum group A-complementing protein |
Swissprots | P23025 Q6LCW7 Q6LD02 Q5T1U9 |
Accessions | AAA92883 AAB60404 AAM18969 EAW58855 P23025 AI961077 AL531629 BC014965 AAH14965 BT019518 AAV38325 CB155090 D14533 BAA03403 DQ893624 ABM84550 DQ895423 ABM86349 HG502281 KC899693 AHF45877 S89853 AAB21861 XM_006717278 XP_006717341 XM_011518988 XP_011517290 XR_929839 NM_000380 NP_000371 NR_027302 |
Function | Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. {ECO:0000269|PubMed:19197159}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:20304803}. |
Tissue Specificity | Expressed in various cell lines and in skin fibroblasts. {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:8543191}. |
Top Pathways | Nucleotide excision repair |
Human XPA full length protein - ab139799 from Abcam
|
||||||||||
XPA Antibody Blocking Peptide - LS-E2747 from LifeSpan Bioscience
|
||||||||||
XPA Antibody Blocking Peptide - LS-E22381 from LifeSpan Bioscience
|
||||||||||
XPA Antibody Blocking Peptide - LS-E9778 from LifeSpan Bioscience
|
||||||||||
XPA Recombinant Protein - H00007507-P01 from Novus Biologicals
|
||||||||||
Recombinant Human XPA Protein - NBP2-22951 from Novus Biologicals
|
||||||||||
XPA-Antibody-C-term-Blocking-peptide - BP13836b from Abgent, a WuXi AppTec company
|
||||||||||
XPA-Antibody-C-term-Blocking-Peptide - BP8784b from Abgent, a WuXi AppTec company
|
||||||||||
Human XPA protein - orb169562 from Biorbyt
|
||||||||||
XPA protein (His tag) - 80R-2636 from Fitzgerald
|
||||||||||
XPA Blocking Peptide - abx063427 from Abbexa
|
||||||||||
XPA / XPAC (1-273, His-tag) - AR50756PU-N from Acris Antibodies
|
||||||||||
XPA / XPAC (1-273, His-tag) - AR50756PU-S from Acris Antibodies
|
||||||||||
XPA / XPAC - H00007507-P01-10 from Acris Antibodies
|
||||||||||
XPA / XPAC - H00007507-P01-25 from Acris Antibodies
|
||||||||||
XPA, 1-273aa Human, His tag, E.coli - 01-P1932 from ARP American Research Products
|
||||||||||
XPA fusion protein - ag9901 from Proteintech Group
|
||||||||||
XPA fusion protein - ag9536 from Proteintech Group
|
||||||||||
XPA Human - PRPS-033 from NeoScientific
|
||||||||||
XPA Peptide - 350530 from ABBIOTEC
|
||||||||||
XPA, 1-273aa Human, His tag, E.coli - GWB-PPST20 from Genway Biotech
|
||||||||||
Recombinant Human XPA, His-tagged - XPA-3751H from Creative Biomart
|
||||||||||
XPA Blocking Peptide - CBP2233 from Cohesion Biosciences
|
||||||||||
XPA (H244) Peptide - BS1492P from Bioworld Technology
|
||||||||||
Recombinant Human DNA repair protein complementing XP-A cells(XPA) - CSB-YP026216HU CSB-EP026216HU CSB-BP026216HU CSB-MP026216HU from Cusabio
|