Gene Symbol | HTN3 |
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Entrez Gene | 3347 |
Alt Symbol | HIS2, HTN2, HTN5 |
Species | Human |
Gene Type | protein-coding |
Description | histatin 3 |
Other Description | PB|basic histidine-rich protein|histatin 5|histatin-3|histatin-4|histatin-5|histatin-6|histatin-7|histatin-8|histatin-9|histidine-rich protein 3|hst |
Swissprots | Q16243 P15516 Q502Z1 |
Accessions | AAA02746 AAB32411 EAX05606 P15516 BC009791 AAH09791 BC095438 AAH95438 BP332860 CB957931 DQ892864 ABM83790 DQ896113 ABM87112 M18372 AAA51830 M26665 AAA58646 NM_000200 NP_000191 |
Function | Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. {ECO:0000269|PubMed:11179305, ECO:0000269|PubMed:8945538}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:14966203}. Note=Secreted by serous acinar and demilune cells. |
Top Pathways | Salivary secretion |
Anti-Histatin 3 / HTN3 Antibody (clone 4G9) - LS-C197471 from LifeSpan Bioscience
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Monoclonal Anti-HTN3 antibody produced in mouse - SAB1402234 from Sigma-Aldrich
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Anti -HTN3 (Histatin-3, Basic Histidine-rich Protein, Hst, Histidine-rich Protein 3, PB,HIS2) - 128160 from USBiological Life Science
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Anti -HTN3 (Histatin-3, Basic Histidine-rich Protein, Hst, Histidine-rich Protein 3, PB,HIS2) (AP) - 128160-AP from USBiological Life Science
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Anti -HTN3 (Histatin-3, Basic Histidine-rich Protein, Hst, Histidine-rich Protein 3, PB,HIS2) (Biotin) - 128160-Biotin from USBiological Life Science
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Anti -HTN3 (Histatin-3, Basic Histidine-rich Protein, Hst, Histidine-rich Protein 3, PB,HIS2) (FITC) - 128160-FITC from USBiological Life Science
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Anti -HTN3 (Histatin-3, Basic Histidine-rich Protein, Hst, Histidine-rich Protein 3, PB,HIS2) (HRP) - 128160-HRP from USBiological Life Science
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Anti -HTN3 (Histatin-3, Basic Histidine-rich Protein, Hst, Histidine-rich Protein 3, PB,HIS2) (PE) - 128160-PE from USBiological Life Science
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Histatin-3 antibody - H00003347-M01 from Acris Antibodies
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HTN3 antibody - 16261-1-AP from Proteintech Group
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HTN3, Monoclonal Antibody - MBS648406 from MyBioSource
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HTN3 Antibody - EPP14146 from Elabscience
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Monoclonal Antibody to Histatin 3 (HTN3) - MAC535Hu21 from Uscn Life Science Inc.
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Polyclonal Antibody to Histatin 3 (HTN3) - PAC535Hu01 from Uscn Life Science Inc.
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Anti-HTN3 monoclonal antibody - DCABH-11953 from Creative Diagnostics
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HTN3, Polyclonal Antibody - MBS2529564 from MyBioSource
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Anti-histatin 3 - 08A003347 from MP Biomedicals
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Monoclonal Antibody to Histatin 3 (HTN3) - MAC535Hu21 from Cloud-clone
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Polyclonal Antibody to Histatin 3 (HTN3) - PAC535Hu01 from Cloud-clone
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Histatin 3 Antibody (4G9) - H00003347-M01 from Novus Biologicals
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Anti-HTN3 monoclonal antibody, clone 5H0 - CABT-BL4888 from Creative Diagnostics
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