| Gene Symbol |
HTN3
|
| Entrez Gene |
3347
|
| Alt Symbol |
HIS2, HTN2, HTN5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histatin 3
|
| Other Description |
PB|basic histidine-rich protein|histatin 5|histatin-3|histatin-4|histatin-5|histatin-6|histatin-7|histatin-8|histatin-9|histidine-rich protein 3|hst
|
| Swissprots |
Q16243 P15516 Q502Z1
|
| Accessions |
AAA02746 AAB32411 EAX05606 P15516 BC009791 AAH09791 BC095438 AAH95438 BP332860 CB957931 DQ892864 ABM83790 DQ896113 ABM87112 M18372 AAA51830 M26665 AAA58646 NM_000200 NP_000191
|
| Function |
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. {ECO:0000269|PubMed:11179305, ECO:0000269|PubMed:8945538}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:14966203}. Note=Secreted by serous acinar and demilune cells.
|
| Top Pathways |
Salivary secretion
|
![Western Blot: Histatin 3 Overexpression Lysate (Adult Normal) [NBP2-11154] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Histatin 3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9759_Histatin%25203%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11154-img0001.jpg)