MCM7

Gene Symbol MCM7
Entrez Gene 4176
Alt Symbol CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104
Species Human
Gene Type protein-coding
Description minichromosome maintenance complex component 7
Other Description CDC47 homolog|DNA replication licensing factor MCM7|homolog of S. cerevisiae Cdc47|minichromosome maintenance deficient 7|protein phosphatase 1, regulatory subunit 104
Swissprots E9PGN9 A4D2A2 A4D2A1 Q15076 P33993 Q96GL1 Q96D34
Accessions CBX85483 CDH61696 EAL23855 EAL23856 EAW76598 EAW76599 EAW76600 P33993 AF279900 AAK07555 AI083651 AK055379 BAG51508 AK096959 BAG53399 AK226175 AK293172 BAG56716 AK314575 BAG37153 AY007130 AAG01994 BC009398 AAH09398 BC013375 AAH13375 D55716 BAA09534 D86748 BAH84845 DA253520 DA397394 DA538092 DQ895947 ABM86873 EU176445 ABW03896 X74796 CAA52803 XM_005250348 XP_005250405 NM_001278595 NP_001265524 NM_005916 NP_005907 NM_182776 NP_877577
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:9305914}.
Subcellular Location Nucleus {ECO:0000250}.
Top Pathways DNA replication, Cell cycle

MCM7-Over-expression-Lysate - LY12879a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag MCM7 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MCM7 gene

MCM7 293T Cell Transient Overexpression Lysate(Denatured) - H00004176-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

MCM7 293 Cell Lysate - 401595 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

MCM7 Overexpression Lysate (Native) - NBL1-12956 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MCM7 Overexpression Lysate (Adult Normal) [NBL1-12956] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MCM7.

MCM7 (h2): 293T Lysate - sc-173959 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

MCM7 Over-expression Lysate Product - GWB-A6A98C from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

MCM7 Overexpression Lysate (Denatured) - H00004176-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human MCM7 Knockdown Stable Cell Line - CSC-DC009319 from Creative biogene

Category Cell Line
Species Human
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