MCM7
| Gene Symbol | MCM7 |
|---|---|
| Entrez Gene | 4176 |
| Alt Symbol | CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104 |
| Species | Human |
| Gene Type | protein-coding |
| Description | minichromosome maintenance complex component 7 |
| Other Description | CDC47 homolog|DNA replication licensing factor MCM7|homolog of S. cerevisiae Cdc47|minichromosome maintenance deficient 7|protein phosphatase 1, regulatory subunit 104 |
| Swissprots | E9PGN9 A4D2A2 A4D2A1 Q15076 P33993 Q96GL1 Q96D34 |
| Accessions | CBX85483 CDH61696 EAL23855 EAL23856 EAW76598 EAW76599 EAW76600 P33993 AF279900 AAK07555 AI083651 AK055379 BAG51508 AK096959 BAG53399 AK226175 AK293172 BAG56716 AK314575 BAG37153 AY007130 AAG01994 BC009398 AAH09398 BC013375 AAH13375 D55716 BAA09534 D86748 BAH84845 DA253520 DA397394 DA538092 DQ895947 ABM86873 EU176445 ABW03896 X74796 CAA52803 XM_005250348 XP_005250405 NM_001278595 NP_001265524 NM_005916 NP_005907 NM_182776 NP_877577 |
| Function | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:9305914}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Top Pathways | DNA replication, Cell cycle |
MCM7 CRISPR/Cas9 KO Plasmid (h) - sc-400900 from Santa Cruz Biotechnology
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MCM7 HDR Plasmid (h) - sc-400900-HDR from Santa Cruz Biotechnology
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MCM7 Double Nickase Plasmid (h) - sc-400900-NIC from Santa Cruz Biotechnology
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MCM7 Double Nickase Plasmid (h2) - sc-400900-NIC-2 from Santa Cruz Biotechnology
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MCM7 CRISPR Activation Plasmid (h) - sc-400900-ACT from Santa Cruz Biotechnology
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MCM7 CRISPR Activation Plasmid (h2) - sc-400900-ACT-2 from Santa Cruz Biotechnology
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MCM7 Lentiviral Activation Particles (h) - sc-400900-LAC from Santa Cruz Biotechnology
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MCM7 Lentiviral Activation Particles (h2) - sc-400900-LAC-2 from Santa Cruz Biotechnology
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MCM7 siRNA (h) - sc-35887 from Santa Cruz Biotechnology
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MCM7 shRNA Plasmid (h) - sc-35887-SH from Santa Cruz Biotechnology
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MCM7 shRNA (h) Lentiviral Particles - sc-35887-V from Santa Cruz Biotechnology
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MCM7 RNAi - H00004176-R04 from Novus Biologicals
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MCM7 RNAi - H00004176-R03 from Novus Biologicals
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MISSION® esiRNA - EHU097271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13124 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13124 from Sigma-Aldrich
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MCM7 siRNA (Human) - CRH2844 from Cohesion Biosciences
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shRNA set against Human MCM7 (NM_005916.3) - SHH339347 from Creative biogene
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shRNA set against Human MCM7(NM_005916.3) - SHH181469 from Creative biogene
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shRNA set against Human MCM7(NM_182776.1) - SHH181487 from Creative biogene
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Human MCM7 siRNA - orb263346 from Biorbyt
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MCM7 shRNA Plasmid (Human) - CHH2844 from Cohesion Biosciences
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MCM7 miRNA 3'UTR clone - MiUTR1H-06165 from Creative biogene
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MCM7 miRNA 3'UTR clone - MiUTR1H-06166 from Creative biogene
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